Document Detail

Inhalation therapy of calcitonin relieves osteoarthritis of the knee.
MedLine Citation:
PMID:  23166425     Owner:  NLM     Status:  MEDLINE    
This study was conducted to determine if nasal salmon calcitonin has additional beneficial effects on clinical symptoms, serum NO, IL-1β, matrix metalloproteinase 3, urinary C-terminal telopeptide type II collagen (CTX-II) levels and MRI findings in knee osteoarthritis (OA) when used concomitantly with exercise therapy. Fifty female patients with knee OA were randomized into two groups. The first group (n = 30) received 200 IU/day nasal salmon calcitonin and a home exercise program; the second group (n = 20) received a home exercise program for 6 months. Compared with baseline,while significant improvements were observed in visual analogue scale (VAS), WOMAC pain, physical function scores, 20-m walking time (P < 0.001) and WOMAC stiffness score (P = 0.041) in the first group, walking and resting VAS, and WOMAC physical function scores were improved (P = 0.029) in the second group after treatment. Significantly increased levels of serum NO and urinary CTX-II (P < 0.001) and significant improvements in the area of medial femoral condyle (P < 0.05) were noted only in the first group. There were significant differences in VAS activation values (P = 0.032) and NO levels (P < 0.001) in the favor of the first group. In conclusion, nasal salmon calcitonin may have possible chondroprotective effects besides its known effects on symptoms in patients with knee OA.
Onur Armagan; Dilek Kaya Serin; Cüneyt Calisir; Ali Dokumacioglu; Merih Ozgen; Setenay Oner; Ozkan Alatas
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-10-30
Journal Detail:
Title:  Journal of Korean medical science     Volume:  27     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-04-26     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1405-10     Citation Subset:  IM    
Department of Physical Therapy and Rehabilitation, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
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MeSH Terms
Bone Density Conservation Agents / therapeutic use*
Calcitonin / therapeutic use*
Collagen Type II / urine
Exercise Therapy
Interleukin-1beta / blood
Magnetic Resonance Imaging
Matrix Metalloproteinase 3 / blood
Middle Aged
Nitric Oxide / blood
Osteoarthritis, Knee / drug therapy*,  radiography
Peptide Fragments / urine
Respiratory Therapy
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Collagen Type II; 0/Interleukin-1beta; 0/Peptide Fragments; 0/collagen II C-telopeptide; 10102-43-9/Nitric Oxide; 47931-85-1/salmon calcitonin; 9007-12-9/Calcitonin; EC Metalloproteinase 3

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