Document Detail


Inhalation of nitrous oxide expands epidural air bubbles.
MedLine Citation:
PMID:  8829407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: Epidural air bubbles are known to persist for more than 24 hours after injection. Nitrous oxide may cause expansion of these bubbles. METHODS: Nine dogs were anesthetized. Ten mL air and 9 mL of iophendylate were injected into the lumbar epidural space. Control animals (n = 3) breathed halothane in 100% oxygen. Experimental animals (n = 6) breathed halothane in 70/30 nitrous oxide/oxygen. Lateral radiographs were taken before and just after injection, and again 3 hours after breathing either 70% nitrous oxide or 100% oxygen. Epidural space pressure was monitored and recorded during these 3 hours. RESULTS: In all experimental animals, an increase in bubble size was observed. In the control animals, bubble size either remained the same or decreased. Epidural space pressure did not change in any animal. CONCLUSIONS: Inhalation of nitrous oxide results in expansion of epidural air bubbles. This may cause displacement of epidural local anesthetics it large volumes of air are present in the epidural space.
Authors:
R Petty; R Stevens; S Erickson; J Lucio; T C Kao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Regional anesthesia     Volume:  21     ISSN:  0146-521X     ISO Abbreviation:  Reg Anesth     Publication Date:    1996 Mar-Apr
Date Detail:
Created Date:  1996-10-16     Completed Date:  1996-10-16     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7707549     Medline TA:  Reg Anesth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  144-8     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, Epidural*
Anesthetics, Inhalation / administration & dosage,  adverse effects*
Animals
Dogs
Epidural Space / pathology*,  radiography
Female
Male
Nitrous Oxide / administration & dosage,  adverse effects*
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 10024-97-2/Nitrous Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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