Document Detail


Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine.
MedLine Citation:
PMID:  22263852     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objectives: The present study was carried out to determine whether inhalation of hydrogen (H(2)) gas protects myocardium against ischemia-reperfusion (I/R) injury in swine. Design: In anesthetized open-chest swine, myocardial stunning was produced by 12-min occlusion of left anterior descending coronary artery (LAD) followed by 90-min reperfusion in the first study. Group A inhaled 100% oxygen, and group B inhaled 2% H(2) plus 98% oxygen during ischemia and reperfusion. In the second study, myocardial infarction was produced by 40-min occlusion of LAD followed by 120-min reperfusion. Group C inhaled 100% oxygen during ischemia and reperfusion. Group Dinhaled 2% H(2) plus 98% oxygen. Group E inhaled 4% H(2) plus 96% oxygen. Results: The change of segment shortening (%SS) from baseline at 90 min after reperfusion in group B was 74 ± 13 (mean ± SD) %, which was significantly higher than that in group A (48 ± 15%). Myocardial infarct size in group E (32 ± 10%), but not in group D (40 ± 9%) was smaller than that in group C (46 ± 6%). Conclusions: Inhalation of 2% H(2) gas improves myocardial stunning, and inhalation of 4% but not 2% H(2) gas reduces myocardial infarct size in swine.
Authors:
Kazuyuki Sakai; Sungsam Cho; Itsuko Shibata; Osamu Yoshitomi; Takuji Maekawa; Koji Sumikawa
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-20
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  -     ISSN:  1651-2006     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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