Document Detail


Inhalation heterogeneity from subresidual volumes in elite divers.
MedLine Citation:
PMID:  20864566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Punctate reopening of the lung from subresidual volumes (sub-RV) is commonly observed in excised lung preparations, either degassed or collapsed to zero transpulmonary pressure, and in the course of reinflation of human lungs when the chest is open, secondary to traumatic or surgical pneumothoraxes. In the course of physiological studies on two elite breath-hold divers, who are able to achieve lung volumes well below traditional RV with glossopharyngeal exsufflation, we used MRI lung imaging with inhaled hyperpolarized (129)Xe to visualize ventilatory patterns. We observed strikingly inhomogeneous inhalation patterns with small inhalation volumes from sub-RV, consistent with reopening of frankly closed airways. On the other hand, two age-matched and two older controls, inhaling from just above RV, showed a much more homogeneous pattern. Our results demonstrate the concept of frank airway closure below RV in young healthy adults with an intact chest wall.
Authors:
Iga Muradyan; Stephen H Loring; Massimo Ferrigno; Peter Lindholm; George P Topulos; Samuel Patz; James P Butler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-09-23
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  109     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-03-25     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1969-73     Citation Subset:  IM    
Affiliation:
Department of Radiology, Brigham and Women's Hospital, LMRC, 221 Longwood Ave., Boston, MA 02115, USA. muradian@bwh.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Diving*
Glossopharyngeal Nerve / physiology*
Humans
Inhalation*
Insufflation*
Lung / physiology*
Lung Volume Measurements
Magnetic Resonance Imaging
Middle Aged
Pulmonary Ventilation*
Time Factors
Xenon Isotopes / administration & dosage
Grant Support
ID/Acronym/Agency:
R01-HL-073632/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Xenon Isotopes
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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