Document Detail

Inhalation of diluted diesel engine emission impacts heart rate variability and arrhythmia occurrence in a rat model of chronic ischemic heart failure.
MedLine Citation:
PMID:  17024498     Owner:  NLM     Status:  MEDLINE    
Both increase in cardiac arrhythmia incidence and decrease in heart rate variability (HRV) have been described following human and experimental animal exposures to air pollutants. However, the potential causal relationship between these two factors remains unclear. Incidence of ventricular arrhythmia and HRV were evaluated during and after a 3 h period of Diesel engine exhaust exposure in ten healthy and ten chronic ischemic heart failure (CHF, 3 months after coronary ligation) Wistar rats using implantable ECG telemetry. Air pollutants were delivered to specifically designed whole body individual exposure chambers at particulate matter concentrations similar to those measured inside cabins of cars inserted in congested urban traffic. Recordings were obtained from unrestrained and unsedated vigil rats. Immediate decrease in RMSSD was observed in both healthy (6.64 +/- 2.62 vs. 4.89 +/- 1.67 ms, P < 0.05) and CHF rats (8.01 +/- 0.89 vs. 6.6 +/- 1.37 ms, P < 0.05) following exposure. An immediate 200-500% increase in ventricular premature beats was observed in CHF rats only. Whereas HRV progressively returned to baseline values within 2.5 h after exposure start, the proarrhythmic effect persisted as late as 5 h after exposure termination in CHF rats. Persistence of ventricular proarrhythmic effects after HRV normalization suggests that HRV reduction is not the mechanism of cardiac arrhythmias in this model. Our methodological approach, closely reflecting the real clinical situations, appeared to be a unique tool to provide further insight into the pathophysiological mechanisms of traffic related airborne pollution health impact.
Frédéric Anselme; Stéphane Loriot; Jean-Paul Henry; Frédéric Dionnet; Jean-Gérard Napoleoni; Christian Thuillez; Jean-Paul Morin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-06
Journal Detail:
Title:  Archives of toxicology     Volume:  81     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-16     Completed Date:  2007-10-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  299-307     Citation Subset:  IM    
Service de Cardiologie, Rouen University Hospital, Rouen, France.
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MeSH Terms
Administration, Inhalation
Air Pollutants / toxicity*
Arrhythmias, Cardiac / chemically induced*,  physiopathology
Cardiac Output, Low / physiopathology
Chronic Disease
Heart Rate / drug effects*
Myocardial Infarction / physiopathology
Rats, Wistar
Vehicle Emissions / toxicity*
Reg. No./Substance:
0/Air Pollutants; 0/Gasoline; 0/Vehicle Emissions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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