Document Detail


Inhalation carcinogenicity of dichloromethane in rats and mice.
MedLine Citation:
PMID:  24909451     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract The carcinogenicity of inhaled dichloromethane (DCM) was examined by exposing groups of 50 F344/DuCrj rats and 50 Crj: BDF1 mice of both sexes to 0, 1000, 2000, or 4000 ppm (w/w) DCM-containing aerosol for 2 years. Inhalation of DCM resulted in increased incidences of subcutis fibromas, mammary gland fibroadenoma, and peritoneum mesotheliomas in male rats; mammary gland fibroadenomas in female rats; and bronchiolar-alveolar adenomas and carcinomas in the lung and hepatocellular adenomas and carcinomas in male and female mice. These results clearly indicate that inhaled DCM is carcinogenic in F344/DuCrj (SPF) rats and Crj: BDF1 (SPF) mice.
Authors:
Shigetoshi Aiso; Makoto Take; Tatsuya Kasai; Hideki Senoh; Yumi Umeda; Michiharu Matsumoto; Shoji Fukushima
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-9
Journal Detail:
Title:  Inhalation toxicology     Volume:  -     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-17     Citation Subset:  -    
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