Document Detail


Inhalation anesthetics augment oxidant-induced pulmonary vasoconstriction: evidence for a membrane effect.
MedLine Citation:
PMID:  3933385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inhalational anesthetics "fluidize" biologic membranes. Since arachidonate metabolism also occurs in cell membranes, anesthetic agents may modify arachidonic acid mediator production. The authors used the isolated perfused rabbit lung preparation to examine the effects of inhalational anesthetics on the production of arachidonate mediators. The oxidant tert-butyl-hydroperoxide (t-bu-OOH) is known to cause pulmonary vasoconstriction by causing increased production of thromboxane A2 (TxA2). The authors administered three anesthetics (halothane, cyclopropane, and nitrous oxide) of widely different potencies, at different dosages, each to three different groups of preparations and challenged the lungs at each anesthetic dose with t-bu-OOH. They found a dose-related augmentation of the pulmonary vasopressor response to t-bu-OOH. Preparations given t-bu-OOH alone showed no change in response over time. Lungs perfused with indomethacin (5 micrograms . ml-1 in Krebs-Henseleit buffer), ventilated with cyclopropane (2 MAC), and challenged with t-bu-OOH showed almost complete inhibition of the response to t-bu-OOH. Indomethacin at this concentration is a specific inhibitor of cyclooxygenase. The authors also have demonstrated significantly increased perfusate levels of thromboxane B2 (TxB2), the inactive metabolite of TxA2, after oxidant challenge during exposure to 2% halothane compared with TxB2 levels before halothane exposure. The authors believe that the augmented pressor response and mediator production occur because of increased substrate (arachidonic acid) availability induced by anesthetic agent.
Authors:
J R Shayevitz; R J Traystman; N F Adkinson; A M Sciuto; G H Gurtner
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  63     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1985-12-20     Completed Date:  1985-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  624-32     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
6-Ketoprostaglandin F1 alpha / biosynthesis
Analysis of Variance
Anesthesia, Inhalation*
Anesthetics / pharmacology*
Animals
Arachidonic Acids / metabolism*
Blood Pressure / drug effects
Cell Membrane / drug effects
Cyclooxygenase Inhibitors
Halothane / pharmacology
Indomethacin / pharmacology
Male
Peroxides / pharmacology*
Pulmonary Artery / drug effects
Pulmonary Circulation / drug effects*
Rabbits
Thromboxane B2 / biosynthesis
Vasoconstriction / drug effects*
tert-Butylhydroperoxide
Grant Support
ID/Acronym/Agency:
1R01 GM 32262/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Anesthetics; 0/Arachidonic Acids; 0/Cyclooxygenase Inhibitors; 0/Peroxides; 151-67-7/Halothane; 53-86-1/Indomethacin; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 75-91-2/tert-Butylhydroperoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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