Document Detail


Inhalation exposure to nickel hydroxide nanoparticles induces systemic acute phase response in mice.
MedLine Citation:
PMID:  24278546     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
It has been proposed that acute phase response can be a mechanism by which inhaled particles exert adverse effects on the cardiovascular system. Although some of the human acute phase proteins have been widely studied as biomarkers of systemic inflammation or cardiovascular diseases, there are only a few studies that investigated the role of serum amyloid P (SAP) , a major acute phase protein in mice. In this study, we investigated the changes in SAP, following inhalation exposure to nickel hydroxide nanoparticles (nano-NH) . We conducted 1) acute (4 h) exposure to nano-NH at 100, 500, and 1000 μg/m(3) and 2) sub-acute (4h/d for 3d) exposure at 1000 μg/m(3), then measured serum SAP protein levels along with hepatic Sap mRNA levels. The results show that inhaled nano-NH can induce systemic acute phase response indicated by increased serum SAP levels and hepatic Sap mRNA levels. To the best of our knowledge, this is the first study showing induction of SAP in response to repeated particle exposure, and the results suggest that SAP can be used as a biomarker for systemic inflammation induced by inhaled particles.
Authors:
Gi Soo Kang; Patricia Anne Gillespie; Lung-Chi Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicological research     Volume:  27     ISSN:  1976-8257     ISO Abbreviation:  Toxicol Res     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2013-11-26     Completed Date:  2013-11-26     Revised Date:  2013-12-16    
Medline Journal Info:
Nlm Unique ID:  101483324     Medline TA:  Toxicol Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  19-23     Citation Subset:  -    
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