| Ingrowth of sympathetic innervation occurs concomitantly with a decrease of ANP in the growing rat cardiac ventricles. | |
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MedLine Citation:
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PMID: 11195087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between the immunohistochemical expression of atrial natriuretic peptide and the occurrence of sympathetic nerve fibres, as visualized by staining for tyrosine hydroxylase, in the growing rat heart was evaluated. Rats were investigated at four different stages from birth to 21 days postnatally. The effects of chemical destruction of sympathetic nerve terminals in neonatal rats on the cardiac atrial natriuretic peptide content were furthermore examined by use of radioimmunoassay. There was in principle a reciprocal pattern of immunoreaction for atrial natriuretic peptide and tyrosine hydroxylase positive innervation in the ventricular myocardium, atrial natriuretic peptide reaction becoming less and less pronounced with the ingrowth of innervation positive for tyrosine hydroxylase. Furthermore, in the peripheral Purkinje fibre network, there was a marked atrial natriuretic peptide immunoexpression and scarce or no nerve fibres throughout the examination period. The radioimmunoassay measurements showed that chemical sympathectomy lead to elevated cardiac levels of atrial natriuretic peptide. The study shows that sympathetic innervation grows into the ventricular parts concomitantly with the occurrence of a decline in atrial natriuretic peptide expression during development of the heart. Furthermore, it is shown that a reversion of the in growth of sympathetic innervation by destruction of cardiac sympathetic nerves at an early stage leads to increased levels of atrial natriuretic peptide in the heart. The results give new evidence to the phenomenon that the atrial natriuretic peptide levels in the ventricular myocardium and the peripheral parts of the conduction system are under influence of the presence of sympathetic innervation. |
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Authors:
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M Hansson; U Kjörell; S Forsgren |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anatomy and embryology Volume: 203 ISSN: 0340-2061 ISO Abbreviation: Anat. Embryol. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-18 Completed Date: 2001-03-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7505194 Medline TA: Anat Embryol (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: 35-44 Citation Subset: IM |
Affiliation:
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Department of Integrative Medical Biology, Umeå University, Sweden. magnus.hansson@anatomy.umu.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Atrial Appendage / growth & development, innervation, metabolism Atrial Natriuretic Factor / metabolism* Axons / metabolism*, ultrastructure Female Heart Conduction System / cytology, growth & development, metabolism Heart Ventricles / growth & development*, innervation*, metabolism Myocardium / cytology, metabolism* Oxidopamine / diagnostic use Pregnancy Radioimmunoassay Rats Rats, Sprague-Dawley Sympathectomy, Chemical / adverse effects Sympathetic Nervous System / cytology, growth & development*, metabolism Tyrosine 3-Monooxygenase / metabolism |
| Chemical | |
Reg. No./Substance:
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1199-18-4/Oxidopamine; 85637-73-6/Atrial Natriuretic Factor; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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