| Ingestion of potato starch containing esterified phosphorus increases alkaline phosphatase activity in the small intestine in rats. | |
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MedLine Citation:
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PMID: 20579526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alkaline phosphatase (ALP) hydrolyzes a variety of monophosphate esters and plays an important role in phosphorus (P) metabolism. Several nutrients in food have been reported to affect intestinal ALP activity in animal models. Previous reports indicated that high levels of P or phosphate in diets decreased intestinal ALP activity in rats. Because potato starch contains considerable amounts of esterified P, unlike other starch-derived plants, we hypothesized that the feeding of potato starch would decrease ALP activity in the intestinal tract. Male Sprague-Dawley rats (7 weeks old) were fed 3 different types of diet containing 60% corn starch or 1 of 2 types of potato starch with different esterified P content for 1 or 5 weeks. Body weight and food intake of each rat were measured every day throughout the experimental periods. At the end of the feeding periods, the small intestine was removed to determine ALP activity in the mucosal tissues. Significant differences were observed in ALP activity in the small intestine between the 2 feeding periods, among the 4 segments of the small intestine, and among the 3 diet groups. Significant positive linear correlations between the amount of P derived from the starch and mucosal ALP activity were obtained in the jejunum and jejunoileum in rats after feeding for 5 weeks. We concluded, contrary to our hypotheses, that the ingestion of potato starch adaptively increases ALP activity in the upper part of the small intestine of growing rats in an esterified P content-dependent manner. |
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Authors:
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Hitoshi Mineo; Nao Morikawa; Sayako Ohmi; Kyo Ishida; Ayaka Machida; Takumi Kanazawa; Hideyuki Chiji; Michihiro Fukushima; Takahiro Noda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition research (New York, N.Y.) Volume: 30 ISSN: 1879-0739 ISO Abbreviation: Nutr Res Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2010-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8303331 Medline TA: Nutr Res Country: United States |
Other Details:
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Languages: eng Pagination: 341-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Faculty of Human Science, Hokkaido Bunkyo University, Eniwa, Hokkaido 061-1449, Japan. mineo@do-bunkyodai.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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metabolism* Animals Esterification Intestinal Mucosa / drug effects*, enzymology Intestine, Small / drug effects*, enzymology Male Phosphorus, Dietary / administration & dosage* Plant Preparations / pharmacology* Rats Rats, Sprague-Dawley Solanum tuberosum / chemistry* Starch / pharmacology* Zea mays / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus, Dietary; 0/Plant Preparations; 9005-25-8/Starch; EC 3.1.3.1/Alkaline Phosphatase |
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