Document Detail

Ingestion of non-caloric liquid diet is sufficient to restore plasma corticosterone level, but not to induce the hypothalamic c-Fos expression in food-deprived rats.
MedLine Citation:
PMID:  18284034     Owner:  NLM     Status:  MEDLINE    
Male Sprague-Dawley rats were subjected to four different conditions; free fed control (FC), 48 h of food deprivation (FD), 1 h of refeeding with chow (RF/CW) or with a non-caloric liquid diet following FD (RF/NC) and then sacrificed for c-Fos immunohistochemistry in the hypothalamic paraventricular nucleus (PVN) and the nucleus tractus of solitarius (NTS). Plasma corticosterone level and the postmortem weight of gastric contents were measured. Plasma level of corticosterone significantly increased during FD, and then decreased within 1 h after ad libitum access to chow or non-caloric liquid diet. c-Fos-ir in the brain regions was not changed by FD; however, significantly increased by chow refeeding, but not by non-caloric diet. Chow, but not the non-caloric, refeeding significantly increased gastric contents. Results suggest that caloric load and/or gastric distension may require for the postprandial activation of neurons in the PVN and NTS, but ingestion of non-caloric palatable mixture may be sufficient to normalize the fasting-induced increase of plasma corticosterone. In conclusion, feeding-related changes in the HPA axis activity may not be related with meal-induced c-Fos expression in the PVN and NTS.
Sang Bae Yoo; Jong-Ho Lee; Vitaly Ryu; Jeong Won Jahng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  10     ISSN:  1028-415X     ISO Abbreviation:  Nutr Neurosci     Publication Date:    2007 Oct-Dec
Date Detail:
Created Date:  2008-02-20     Completed Date:  2008-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-7     Citation Subset:  IM    
Department of Oral and Maxillofacial Surgery, Dental Research Institute, Seoul National University School of Dentistry, Seoul 110-768, South Korea.
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MeSH Terms
Corticosterone / blood*
Energy Intake*
Food Deprivation*
Hypothalamus / chemistry*
Organ Size
Paraventricular Hypothalamic Nucleus / chemistry
Proto-Oncogene Proteins c-fos / analysis*
Rats, Sprague-Dawley
Solitary Nucleus / chemistry
Stomach / anatomy & histology
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Solutions; 50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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