| Ingestion of (n-3) Fatty Acids Augments Basal and Platelet Activating Factor-Induced Permeability to Dextran in the Rat Mesenteric Vascular Bed. | |
| | |
MedLine Citation:
|
PMID: 21775525 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Loss of intestinal barrier function and subsequent edema formation remains a serious clinical problem leading to hypoperfusion, anastomotic leakage, bacterial translocation, and inflammatory mediator liberation. The inflammatory mediator platelet activating factor (PAF) promotes eicosanoid-mediated edema formation and vasoconstriction. Fish oil-derived (n-3) fatty acids (FA) favor the production of less injurious eicosanoids but may also increase intestinal paracellular permeability. We hypothesized that dietary (n-3) FA would ameliorate PAF-induced vasoconstriction and enhance vascular leakage of dextran tracers. Rats were fed either an (n-3) FA-rich diet (EPA-rich diet; 4.0 g/kg EPA, 2.8 g/kg DHA) or a control diet (CON diet; 0.0 g/kg EPA and DHA) for 3 wk. Subsequently, isolated and perfused small intestines were stimulated with PAF and arterial pressure and the translocation of fluid and macromolecules from the vasculature to lumen and lymphatics were analyzed. In intestines of rats fed the EPA-rich diet, intestinal phospholipids contained up to 470% more EPA and DHA at the expense of arachidonic acid (AA). The PAF-induced increase in arterial pressure was not affected by the EPA-rich diet. However, PAF-induced fluid loss from the vascular perfusate was higher in intestines of rats fed the EPA-rich diet. This was accompanied by a greater basal loss of dextran from the vascular perfusate and a higher PAF-induced transfer of dextran from the vasculature to the lumen (P = 0.058) and lymphatics. Our data suggest that augmented intestinal barrier permeability to fluid and macromolecules is a possible side effect of (n-3) FA-rich diet supplementation. |
| | |
Authors:
|
Heike Dombrowsky; Ingmar Lautenschläger; Nicole Zehethofer; Buko Lindner; Holger Schultz; Stefan Uhlig; Inéz Frerichs; Norbert Weiler |
Related Documents
:
|
18670665 - Estimating the cardiovascular mortality burden attributable to the european common agri... 20009215 - Neuronutrition and alzheimer's disease. 2243435 - Cholesterol and coronary heart disease. future directions. 9232085 - A changing hausa diet. 17935245 - Effects of two whole blood systems (dali and liposorber d) for ldl apheresis on lipids ... 16443925 - Altered mammary gland development in male rats exposed to genistein and methoxychlor. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-20 |
Journal Detail:
|
Title: The Journal of nutrition Volume: - ISSN: 1541-6100 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Anesthesiology and Intensive Care Medicine, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fat Mass Is Inversely Associated with Serum Carboxymethyl-Lysine, An Advanced Glycation End Product,...
Next Document: A High-Fat, High-Fructose Diet Accelerates Nutrient Absorption and Impairs Net Hepatic Glucose Uptak...