Document Detail


Ingestion of broccoli sprouts does not improve endothelial function in humans with hypertension.
MedLine Citation:
PMID:  20805984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
METHODS: 40 hypertensive individuals without diabetes and with normal levels of cholesterol were examined. The participants were randomized either to ingest 10 g dried broccoli sprouts, a natural donor of glucosinolates with high in vitro antioxidative potential, for a 4 week period or to continue their ordinary diet and act as controls. Blood pressure, endothelial function measured by flow mediated dilation (FMD) and blood samples were obtained from the participants every other week and the content of glucosinolates was measured before and after the study. Measurements were blinded to treatment allocation.
RESULTS: In the interventional group overall FMD increased from 4% to 5.8% in the interventional group whereas in the control group FMD was stable (4% at baseline and 3.9% at the end of the study). The change in FMD in the interventional group was mainly due to a marked change in FMD in two participants while the other participants did not have marked changes in FMD. The observed differences were not statistically significant. Likewise significant changes in blood pressure or blood samples were not detected between or within groups. Diastolic blood pressure stayed essentially unchanged in both groups, while the systolic blood pressure showed a small non significant decrease (9 mm Hg) in the interventional group from a value of 153 mm Hg at start.
CONCLUSION: Daily ingestion of 10 g dried broccoli sprouts does not improve endothelial function in the presence of hypertension in humans.
TRIAL REGISTRATION: Clinicaltrials.gov NCT00252018.
Authors:
Buris Christiansen; Natalia Bellostas Muguerza; Atheline Major Petersen; Britt Kveiborg; Christian Rask Madsen; Hermann Thomas; Nikolaj Ihlemann; Jens Christian Sørensen; Lars Køber; Hilmer Sørensen; Christian Torp-Pedersen; Helena Domínguez
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-08-27
Journal Detail:
Title:  PloS one     Volume:  5     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-31     Completed Date:  2010-11-04     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e12461     Citation Subset:  IM    
Affiliation:
Department of Oncology, Copenhagen University Hospital, Herlev Hospital, Region Hovedstaden, Denmark. buris@dadlnet.dk
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00252018
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Circulation
Blood Pressure
Brassica* / chemistry
Eating*
Endothelium, Vascular / pathology*
Female
Glucosinolates / analysis
Humans
Hypertension / pathology*,  physiopathology*
Male
Middle Aged
Vasodilation
Chemical
Reg. No./Substance:
0/Glucosinolates
Comments/Corrections

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