Document Detail

Ingestion of Proteoglycan Fraction from Shark Cartilage Increases Serum Inhibitory Activity against Matrix Metalloproteinase-9 and Suppresses Development of N-Nitrosobis(2-Oxopropyl)Amine-Induced Pancreatic Duct Carcinogenesis in Hamster.
MedLine Citation:
PMID:  22225405     Owner:  NLM     Status:  Publisher    
A water-extract of shark cartilage was fractionated into acidic and basic fractions by preparative isoelectric focusing on the basis of amphoteric nature of samples. The acidic fraction was further fractionated into ethanol-soluble and -precipitate fractions. After the carcinogenesis treatment using N-nitrosobis(2-oxopropyl)amine, hamsters received the diet containing each fraction or purified chondroichin sulfate to give 0.4% (w/w) for 50 days. Only administration of the acidic ethanol-precipitate fraction-containing diet significantly increased serum inhibitory activity against matrix metalloproteinase (MMP)-9 and reduced the number of adenocarcinomas in pancreatic duct. The active fraction predominantly consisted of chondroichin sulfate-containing proteoglycan. However, the purified chondroichin sulfate had no significant activity. These results suggest that protein moiety of the proteoglycan might be involved in the increase of serum inhibitory activity against MMP-9 and suppression of pancreatic carcinogenesis in hamster.
Kenji Sato; Tsukasa Kitahashi; Shoko Ikawa; Akika Sakamoto; Yoshihiro Nomura; Toshifumi Tsujiuchi; Kenji Shimizu; Shuji Sasabe; Eun Young Park; Yasushi Nakamura; Masahiro Tsutsumi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-29
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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