Document Detail

Infusions of chemicals into the brain and the development of sustained elevations of blood pressure in the rat.
MedLine Citation:
PMID:  6804729     Owner:  NLM     Status:  MEDLINE    
Osmotic minipumps were used to infuse carbachol chloride (1.23 micrograms/hr), echothiophate iodide (0.5 microgram/hr), histamine dihydrochloride (10 micrograms/hr), prostaglandin E2 (1.0 microgram/hr) and thyrotropin-releasing hormone (0.5 and 5.0 micrograms/hr) solutions into the cerebral ventricles of unanesthetized rats and blood pressure was measured by the tail-cuff method. Histamine dihydrochloride, prostaglandin E2 and thyrotropin-releasing hormone produced an initial rise in blood pressure, but were not effective in producing sustained elevations in blood pressure. Carbachol infusions elevated blood pressure throughout the 7-day infusion period when results were compared to saline-infused animals. Infusions of echothiophate iodide, an anticholinesterase agent, produced an initial rise in blood pressure but these pressor effects were not sustained. In animals infused with echothiophate for 7 days, the pressor response to a challenge dose of echothiophate was diminished.
Y Y Wu; E T Wei
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  30     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-07-19     Completed Date:  1982-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1537-45     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Brain / drug effects*
Carbachol / pharmacology
Delayed-Action Preparations
Echothiophate Iodide / pharmacology
Histamine / pharmacology
Injections, Intraventricular
Prostaglandins E / pharmacology
Rats, Inbred Strains
Thyrotropin-Releasing Hormone / pharmacology
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Prostaglandins E; 24305-27-9/Thyrotropin-Releasing Hormone; 363-24-6/Dinoprostone; 51-45-6/Histamine; 51-83-2/Carbachol; 513-10-0/Echothiophate Iodide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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