| Infusion therapy at outpatient clinic in chronic end-stage heart failure | |
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MedLine Citation:
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PMID: 17552290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine whether drug infusions at ambulatory clinic in patients with end stage congestive heart failure are safe and reduce the period of hospitalization. METHODS: Between May 2000 and November 2006, 21 ambulatory patients with end stage congestive heart failure were treated with infusions of the natriuretic peptide, carperitide (6 patients, 43 infusions of mean 0.033 microg/kg/min for mean 3.7 hr), the phosphodiesterase inhibitor, olprinone (19 patients, 75 infusions of mean 0.11 microg/kg/min for mean 3.8 hr), or the catecholamines, dopamine or dobutamine(5 patients, 89 infusions of mean 3.3 microg/kg/min for mean 3.2 hr). RESULTS: Systolic and diastolic blood pressure was lower after infusion of carperitide, whereas catecholamines increased systolic blood pressure and heart rate (all differences from baseline p < 0.0001). Olprinone changed neither blood pressure nor heart rate. No adverse effect was observed, including arrhythmias or change in blood pressure requiring cessation of drug infusion. Mean urinary output per infusion was 979 ml for carperitide, 720ml for olprinone, and 594ml for catecholamines. There was no correlation between mean urinary output and dose of furosemide administered during intermittent infusion therapy. There was a close correlation between pre-infusion blood pressure and urinary output(systolic: p < 0.05; diastolic: p < 0.0001). Infusion therapy reduced the length of hospitalization (p < 0.05) in 7 patients from April 2005. CONCLUSIONS: Ambulatory, low-dose infusion therapy may not decrease the mortality of patients in end-stage congestive heart failure, but was safe and might represent an acceptable end-of-life therapeutic option. |
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Authors:
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Kiyoto Nishi; Yukihito Sato; Tadashi Miyamoto; Ryoji Taniguchi; Tatsuhiko Matsuoka; Yasuhide Kuwabara; Kei Isoda; Keiichirou Yamane; Tsutomu Hatakenaka; Keiko Fujinaga; Hisayoshi Fujiwara; Yoshiki Takatsu |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Journal of cardiology Volume: 49 ISSN: 0914-5087 ISO Abbreviation: J Cardiol Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-06-07 Completed Date: 2007-07-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: Japan |
Other Details:
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Languages: jpn Pagination: 251-8 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Hyogo Prefectural Amagasaki Hospital, Higashidaimotsucho 1-1-1, Amagasaki, Hyogo. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Ambulatory Care* Ambulatory Care Facilities Atrial Natriuretic Factor / administration & dosage Blood Pressure Drug Administration Schedule Female Heart Failure / drug therapy*, physiopathology Heart Rate Humans Infusions, Intravenous Length of Stay / statistics & numerical data Male Natriuretic Peptide, Brain / administration & dosage* Phosphodiesterase Inhibitors / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/NPPA protein, human; 0/Phosphodiesterase Inhibitors; 114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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