Document Detail

Infusion rate of propofol and jugular venous oxygen saturation.
MedLine Citation:
PMID:  18008124     Owner:  NLM     Status:  MEDLINE    
We compared jugular venous blood oxygen saturation (Sj(O) (2)) and the arterial-to-jugular-bulb venous oxygen content difference (AjD(O) (2)) between bispectral index (BIS) values of 40 and 60, adjusted by the infusion rate of propofol. Eighteen postoperative neurosurgical patients (Glasgow Coma Scale [GCS] scores, 11-15) were enrolled. Normocapnia, normothermia, and a mean arterial blood pressure greater than 70 mmHg were maintained. At BIS values of 40 and 60, hemoglobin, oxygen saturation, and the oxygen partial pressure of arterial and jugular venous blood were measured. Sj(O) (2) at BIS40 (58 +/- 9%) was significantly (P < 0.01) lower than that at BIS60 (63 +/- 10%), and AjD(O) (2) at BIS40 (6.3 +/- 1.5 ml.dl(-1)) was significantly (P < 0.01) higher than that at BIS60 (5.7 +/- 1.5 ml.dl(-1); mean +/- SD). At BIS40, status defined as Sj(O) (2) less than 50% was observed in 3 patients, while this status was observed in 1 patient at BIS60. In conclusion, in patients with postoperative neurosurgical surgery (GCS scores, 11-15), decreases of propofol infusion to adjust the BIS value from 40 to 60 increase the cerebral oxygen balance.
Yasunori Haranishi; Yasuhiro Kuroda; Yasutoshi Matayoshi; Hisashi Tamura; Hideo Oka; Kumiko Nakamura; Toru Gohara; Yoshiaki Nagusa; Kaori Yoshitomi
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Publication Detail:
Type:  Journal Article     Date:  2007-11-01
Journal Detail:
Title:  Journal of anesthesia     Volume:  21     ISSN:  0913-8668     ISO Abbreviation:  J Anesth     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8905667     Medline TA:  J Anesth     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  516-8     Citation Subset:  IM    
Department of Anesthesia and Intensive Care Medicine, Yamaguchi Grand Medical Center, Yamaguchi, Japan.
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MeSH Terms
Aged, 80 and over
Anesthetics, Intravenous / administration & dosage*
Brain / metabolism
Cerebrovascular Circulation
Infusions, Intravenous
Jugular Veins / metabolism*
Middle Aged
Oxygen / blood*
Propofol / administration & dosage*
Reg. No./Substance:
0/Anesthetics, Intravenous; 2078-54-8/Propofol; 7782-44-7/Oxygen

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