| Infusion-embolization. | |
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MedLine Citation:
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PMID: 6093984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transcatheter intra-arterial therapy for the cancer patient encompasses infusion of chemotherapy and embolization. Intra-arterial infusion of chemotherapeutic agents has been resurrected because of the availability of new drugs, combinations of drugs, and the capability of percutaneous selective catheter placement. Intra-arterial infusion has been effective in patients with carcinomas of the liver, bladder, prostate, uterus, ovary, and lung and in bone and soft tissue sarcomas, melanomas, and tumors of the brain. Embolization of the arterial supply, creating ischemia of the neoplasm, has been employed in the therapeutic management of patients with primary and secondary neoplasms of the liver, kidney, and bone. The median survival of 100 patients with neoplasms of the liver from the time of hepatic artery embolization was 11.5 months. In 100 patients with pulmonary metastases from carcinoma of the kidney, 28 experienced a response to renal artery embolization, a therapeutic delay of 4 to 7 days, nephrectomy, and Depo-Provera (medroxyprogesterone). Seven of 12 patients with giant cell tumor of the pelvis and lumbar spine responded to arterial embolization after all other therapy failed. Chemoembolization, the combination of arterial infusion of chemotherapy and embolization, can be accomplished by the use of microencapsulated agents, liposomes, and particulate emboli with drugs. This approach integrates the advantages of infusion and occlusion, and has considerable potential. Intra-arterial immunotherapy has been initiated with bacillus Calmette-Guerin (BCG) administration into renal neoplasms in patients with metastatic disease. |
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Authors:
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S Wallace; C Charnsangavej; C H Carrasco; W Bechtel |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cancer Volume: 54 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1984-12-28 Completed Date: 1984-12-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2751-65 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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administration & dosage* Bone Cysts / therapy Bone Neoplasms / secondary, therapy Brain Neoplasms / therapy Breast Neoplasms / therapy Carcinoma, Hepatocellular / therapy Colonic Neoplasms / therapy Embolization, Therapeutic* / adverse effects Female Giant Cell Tumors / therapy Humans Infusions, Intra-Arterial Kidney Neoplasms / therapy Liver Circulation Liver Neoplasms / therapy Neoplasms / therapy* Osteosarcoma / therapy Urinary Bladder Neoplasms / therapy Uterine Cervical Neoplasms / therapy |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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