Document Detail

Infrared-monitored cold response in the assessment of Raynaud's phenomenon.
MedLine Citation:
PMID:  16309469     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Evaluation of treatments for Raynaud's phenomenon (RP) requires objective response parameters in addition to clinical activity scores. Thermographic monitoring of fingertip re-warming after cold challenge has been widely used but usually requires sophisticated equipment. We have previously shown that fingertip re-warming after cold challenge follows a first-order transient response curve that can be described by a single variable, designated tau. OBJECTIVES: Here, we describe a novel device termed a duosensor, which records the tau value upon cold challenge in an automated manner. METHODS: We determined tau values in healthy probands, patients with primary or secondary RP associated with autoimmune disease and patients with scleroderma-associated RP following cold challenge, to determine assay variability, sensitivity and specificity. RESULTS: Duosensor-based thermography exhibited low intraindividual variability in healthy probands. As expected, tau values in RP patients were significantly increased compared with controls (8.08 +/- 3.65 min vs. 3.23 +/- 1.65 min). The duosensor-determined tau value yielded a specificity of 94.6% and predictive value of 95.3% for the presence of RP in a retrospective analysis of 139 patients. Furthermore, in a cohort of scleroderma patients with RP, patient self-assessment of RP severity correlated with tau values. CONCLUSIONS: Taken together, the present data suggest that tau value determination provides a suitable outcome measure for clinical studies of novel RP treatments. As the duosensor is a simple stand-alone device requiring no supporting equipment and minimal personnel attention, it should allow RP activity monitoring even in clinical settings with minimal technical infrastructure.
J Foerster; S Wittstock; S Fleischanderl; A Storch; G Riemekasten; O Hochmuth; B Meffert; H Meffert; M Worm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  31     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-11-28     Completed Date:  2006-05-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6-12     Citation Subset:  IM    
Clinic for Dermatology, Charité, Berlin, Germany.
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MeSH Terms
Body Temperature / physiology
Cohort Studies
Cold Temperature*
Fingers / physiopathology*
Infrared Rays
Plethysmography / instrumentation,  methods
Predictive Value of Tests
Raynaud Disease / diagnosis*,  physiopathology
Regional Blood Flow / physiology
Retrospective Studies
Scleroderma, Systemic / diagnosis,  physiopathology
Sensitivity and Specificity
Severity of Illness Index
Thermography / methods

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