| Infrared-monitored cold response in the assessment of Raynaud's phenomenon. | |
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MedLine Citation:
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PMID: 16309469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Evaluation of treatments for Raynaud's phenomenon (RP) requires objective response parameters in addition to clinical activity scores. Thermographic monitoring of fingertip re-warming after cold challenge has been widely used but usually requires sophisticated equipment. We have previously shown that fingertip re-warming after cold challenge follows a first-order transient response curve that can be described by a single variable, designated tau. OBJECTIVES: Here, we describe a novel device termed a duosensor, which records the tau value upon cold challenge in an automated manner. METHODS: We determined tau values in healthy probands, patients with primary or secondary RP associated with autoimmune disease and patients with scleroderma-associated RP following cold challenge, to determine assay variability, sensitivity and specificity. RESULTS: Duosensor-based thermography exhibited low intraindividual variability in healthy probands. As expected, tau values in RP patients were significantly increased compared with controls (8.08 +/- 3.65 min vs. 3.23 +/- 1.65 min). The duosensor-determined tau value yielded a specificity of 94.6% and predictive value of 95.3% for the presence of RP in a retrospective analysis of 139 patients. Furthermore, in a cohort of scleroderma patients with RP, patient self-assessment of RP severity correlated with tau values. CONCLUSIONS: Taken together, the present data suggest that tau value determination provides a suitable outcome measure for clinical studies of novel RP treatments. As the duosensor is a simple stand-alone device requiring no supporting equipment and minimal personnel attention, it should allow RP activity monitoring even in clinical settings with minimal technical infrastructure. |
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Authors:
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J Foerster; S Wittstock; S Fleischanderl; A Storch; G Riemekasten; O Hochmuth; B Meffert; H Meffert; M Worm |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental dermatology Volume: 31 ISSN: 0307-6938 ISO Abbreviation: Clin. Exp. Dermatol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-11-28 Completed Date: 2006-05-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 6-12 Citation Subset: IM |
Affiliation:
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Clinic for Dermatology, Charité, Berlin, Germany. john.foerster@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Body Temperature
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physiology Cohort Studies Cold Temperature* Fingers / physiopathology* Humans Infrared Rays Plethysmography / instrumentation, methods Predictive Value of Tests Raynaud Disease / diagnosis*, physiopathology Regional Blood Flow / physiology Retrospective Studies Scleroderma, Systemic / diagnosis, physiopathology Sensitivity and Specificity Severity of Illness Index Thermography / methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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