Document Detail

Infrared fluorescence videomicroscopy of skin capillaries with indocyanine green.
MedLine Citation:
PMID:  3583575     Owner:  NLM     Status:  MEDLINE    
A new intravital capillary microscopic technique is described using intravenous indocyanine green (Cardiogreen) in combination with a special filter set, an infrared sensitive microchip videocamera and a television-recording system. The technique was used to measure arterial and venous limb capillary diameters in 29 nailfold capillaries from 11 healthy volunteers. The results were compared with measurements of erythrocyte column diameters from the same capillaries. Erythrocyte column diameters were 68% of arterial and venous limb capillary diameters determined with indocyanine green fluorescence videomicroscopy. (Arterial limb: 12.1 +/- 3.0 micron versus 17.8 +/- 3.9 micron; Venous limb: 13.7 +/- 4.1 micron versus 20.1 +/- 4.4 micron) (p less than 0.01). As indocyanine green is nearly 100% protein bound, these differences of 5-7 micron presumably correspond to the plasmatic zone interposed between the erythrocytes and the capillary wall. Other potential uses for the technique in clinical investigations of microcirculatory disturbances are briefly discussed.
G Moneta; M Brülisauer; K Jäger; A Bollinger
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation     Volume:  6     ISSN:  0167-6865     ISO Abbreviation:  Int J Microcirc Clin Exp     Publication Date:  1987  
Date Detail:
Created Date:  1987-07-23     Completed Date:  1987-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8400122     Medline TA:  Int J Microcirc Clin Exp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  25-34     Citation Subset:  IM    
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MeSH Terms
Capillaries / anatomy & histology
Erythrocytes / cytology
Indocyanine Green / administration & dosage,  diagnostic use*
Infrared Rays
Injections, Intravenous
Microscopy, Fluorescence / methods*
Middle Aged
Nails / blood supply
Skin / blood supply*
Video Recording
Reg. No./Substance:
3599-32-4/Indocyanine Green

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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