Document Detail

Informativeness of twin-nuclear family and nuclear family designs for segregation analysis.
MedLine Citation:
PMID:  1756946     Owner:  NLM     Status:  MEDLINE    
This brief note examines the precision of segregation parameter estimates from both twin-nuclear family and conventional nuclear family designs. The program MENDEL was used to derive expected frequencies of different family patterns of affectation (with fixed sibship size) under various single gene models, and then to estimate the standard errors (and information) associated with gene frequency and penetrance values at given sample sizes. As might be expected, a 2- to 5-fold increase in relative efficiency was found for the same family size if families included an MZ twin pair among their offspring. The methods used allow convenient calculation of expected informativeness of a given study design.
D L Duffy; L J Eaves
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genetic epidemiology     Volume:  8     ISSN:  0741-0395     ISO Abbreviation:  Genet. Epidemiol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-02-03     Completed Date:  1992-02-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8411723     Medline TA:  Genet Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  231-5     Citation Subset:  IM    
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
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MeSH Terms
Epidemiologic Methods
Models, Genetic*
Nuclear Family*
Selection, Genetic
Twins, Monozygotic / genetics*
Grant Support

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