Document Detail

Informative value of clinical research on multislice computed tomography in the diagnosis of coronary artery disease: A systematic review.
MedLine Citation:
PMID:  18760849     Owner:  NLM     Status:  MEDLINE    
Multislice Spiral Computed Tomography (MSCT) is an emerging non-invasive diagnostic modality to detect coronary artery disease, which may alter diagnostic pathways and change the current clinical role of conventional coronary angiography. AIMS: To retrieve and critically assess information from the available literature on MSCT (>/=16-slice) concerning its diagnostic accuracy, safety, applicability, clinical impact and cost-effectiveness. METHODS AND RESULTS: Articles published between January 2002 and March 2007 were identified through searches of the Cochrane Library, MEDLINE, and other websites of manufacturers, cardiac professional societies, guidelines and abstracts from conference meetings. We identified 1768 potentially relevant articles: 262 out of these were considered eligible for full evaluation and 150 were selected (57 assessed diagnostic accuracy, 130 applicability, 103 safety, 1 clinical impact and none cost-effectiveness). The pre test probability of coronary artery disease was 56.7% (95% Confidence Interval: 55.1%-58.3%). A positive MSCT finding (pooled LR+: 5.4 (4.4-6.7)) increased the probability of CAD to 87.7% (84.3%-90.3%), whereas a negative MSCT result (pooled LR-: 0.09 (0.07-0.12)) reduced the probability of CAD to 10.7% (7.9%-14.4%). CONCLUSIONS: MSCT is a promising technology for the assessment of coronary artery stenosis. However, the available literature is of limited value in providing guidance to support the development of policies for its appropriate utilization in clinical practice.
Gian Luca Di Tanna; Elena Berti; Elisa Stivanello; Filippo Cademartiri; Stephan Achenbach; Maria Domenica Camerlingo; Roberto Grilli
Related Documents :
17968119 - Covicad: comprehensive visualization of coronary artery disease.
20626669 - Traditional cardiovascular risk factors and severity of angiographic coronary artery di...
16122719 - Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility...
708539 - Diagnosis of coronary artery disease by estimation of coronary sinus lactate.
16218429 - Long-term follow-up of a patient with kawasaki disease and coronary aneurysm associated...
14228239 - Anticoagulant therapy in coronary artery disease: a therapeutic enigma.
24053359 - Non-invasive evaluation of energy loss in the pulmonary arteries using 4d phase contras...
9428439 - Spontaneous perirenal hemorrhage after rupture of an aneurysm in case of polyarteritis ...
15200989 - Factors affecting patency of internal thoracic artery graft: clinical and angiographic ...
Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2008-08-30
Journal Detail:
Title:  International journal of cardiology     Volume:  130     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  386-404     Citation Subset:  IM    
Agency for Health and Social Care of Emilia-Romagna, Bologna, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Coronary Angiography*
Coronary Artery Disease / radiography*
Tomography, X-Ray Computed / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Echocardiographic strain and strain rate imaging--clinical applications.
Next Document:  Moral hazard in insurance, value-based cost sharing, and the benefits of blissful ignorance.