Document Detail


Informative Dorfman screening.
MedLine Citation:
PMID:  21762119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since the early 1940s, group testing (pooled testing) has been used to reduce costs in a variety of applications, including infectious disease screening, drug discovery, and genetics. In such applications, the goal is often to classify individuals as positive or negative using initial group testing results and the subsequent process of decoding of positive pools. Many decoding algorithms have been proposed, but most fail to acknowledge, and to further exploit, the heterogeneous nature of the individuals being screened. In this article, we use individuals' risk probabilities to formulate new informative decoding algorithms that implement Dorfman retesting in a heterogeneous population. We introduce the concept of "thresholding" to classify individuals as "high" or "low risk," so that separate, risk-specific algorithms may be used, while simultaneously identifying pool sizes that minimize the expected number of tests. When compared to competing algorithms which treat the population as homogeneous, we show that significant gains in testing efficiency can be realized with virtually no loss in screening accuracy. An important additional benefit is that our new procedures are easy to implement. We apply our methods to chlamydia and gonorrhea data collected recently in Nebraska as part of the Infertility Prevention Project.
Authors:
Christopher S McMahan; Joshua M Tebbs; Christopher R Bilder
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-07-15
Journal Detail:
Title:  Biometrics     Volume:  68     ISSN:  1541-0420     ISO Abbreviation:  Biometrics     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-26     Completed Date:  2012-07-31     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0370625     Medline TA:  Biometrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-96     Citation Subset:  IM    
Copyright Information:
© 2011, The International Biometric Society.
Affiliation:
Department of Statistics, University of South Carolina, Columbia, South Carolina 29208, USA.
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MeSH Terms
Descriptor/Qualifier:
Biometry / methods*
Chlamydia Infections / epidemiology*
Data Interpretation, Statistical*
Gonorrhea / epidemiology*
Humans
Mass Screening / methods*
Nebraska / epidemiology
Risk Assessment / methods*
Risk Factors
Grant Support
ID/Acronym/Agency:
R01 AI067373/AI/NIAID NIH HHS; R01 AI067373/AI/NIAID NIH HHS; R01 AI067373-02/AI/NIAID NIH HHS
Comments/Corrections

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