| Informative Dorfman screening. | |
| | |
MedLine Citation:
|
PMID: 21762119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Since the early 1940s, group testing (pooled testing) has been used to reduce costs in a variety of applications, including infectious disease screening, drug discovery, and genetics. In such applications, the goal is often to classify individuals as positive or negative using initial group testing results and the subsequent process of decoding of positive pools. Many decoding algorithms have been proposed, but most fail to acknowledge, and to further exploit, the heterogeneous nature of the individuals being screened. In this article, we use individuals' risk probabilities to formulate new informative decoding algorithms that implement Dorfman retesting in a heterogeneous population. We introduce the concept of "thresholding" to classify individuals as "high" or "low risk," so that separate, risk-specific algorithms may be used, while simultaneously identifying pool sizes that minimize the expected number of tests. When compared to competing algorithms which treat the population as homogeneous, we show that significant gains in testing efficiency can be realized with virtually no loss in screening accuracy. An important additional benefit is that our new procedures are easy to implement. We apply our methods to chlamydia and gonorrhea data collected recently in Nebraska as part of the Infertility Prevention Project. |
| | |
Authors:
|
Christopher S McMahan; Joshua M Tebbs; Christopher R Bilder |
Related Documents
:
|
21593559 - Screening for alzheimer's disease among illiterate elderly: accuracy analysis for multi... 22029559 - Metacognition in taiwan: students' calibration of comprehension and performance. 21134679 - Additional studies on shape selectivity by using the carotenoid test to classify c18 bo... 22251259 - Cost-effectiveness of cervical cancer screening: cytology versus human papillomavirus d... 22129189 - Meta-analysis of clinical studies of diagnostic tests: developments in how the receiver... 23578169 - Comparison of the two fully automated anti-hcmv igg assays: abbott architect cmv igg as... 12081129 - Drug eruptions: the value of oral rechallenge test and patch test. 126639 - Use of the reversed passive arthus reaction as a test for anti-inflammatory agents. 3349759 - The low physical working capacity of thyrotoxic patients is not normalized by oral anti... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-07-15 |
Journal Detail:
|
Title: Biometrics Volume: 68 ISSN: 1541-0420 ISO Abbreviation: Biometrics Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-03-26 Completed Date: 2012-07-31 Revised Date: 2013-05-24 |
Medline Journal Info:
|
Nlm Unique ID: 0370625 Medline TA: Biometrics Country: United States |
Other Details:
|
Languages: eng Pagination: 287-96 Citation Subset: IM |
Copyright Information:
|
© 2011, The International Biometric Society. |
Affiliation:
|
Department of Statistics, University of South Carolina, Columbia, South Carolina 29208, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biometry
/
methods* Chlamydia Infections / epidemiology* Data Interpretation, Statistical* Gonorrhea / epidemiology* Humans Mass Screening / methods* Nebraska / epidemiology Risk Assessment / methods* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
|
R01 AI067373/AI/NIAID NIH HHS; R01 AI067373-02/AI/NIAID NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Local multiplicity adjustment for the spatial scan statistic using the Gumbel distribution.
Next Document: Resveratrol ameliorates TNF?-mediated suppression of erythropoiesis in human CD34(+) cells via modul...