Document Detail


Information transmission rates of cat retinal ganglion cells.
MedLine Citation:
PMID:  14602836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the information encoded in retinal spike trains and how it might be decoded by recipient neurons in the brain, we recorded from individual cat X and Y ganglion cells and visually stimulated them with randomly modulated patterns of various contrast and spatial configuration. For each pattern, we estimated the information rate of the cells using linear or nonlinear algorithms and for some patterns by directly measuring response probability distributions. We show that ganglion cell spike trains contain information from the receptive field center and surround, that the center and surround have similar signaling capacity, that antagonism between the mechanisms reduces information transmission, and that the total information rate is limited. We also show that a linear decoding algorithm can capture all of the information available in retinal spike trains about weak inputs, but it misses a substantial amount about strong inputs. For the strongest stimulus we used, the information rate of the best linear decoder averaged 40-70 bits/s across ganglion cell types, while the directly measured rate was around 20-40 bits/s greater. This implies that under certain stimulus conditions, visual information is encoded in the temporal structure of retinal spike trains and that a nonlinear decoding algorithm is needed to extract the temporally coded information. Using simulated spike trains, we demonstrate that much of the temporal structure may be explained by the threshold for spike generation and is not necessarily indicative of a complex coding scheme.
Authors:
Christopher L Passaglia; John B Troy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2003-11-05
Journal Detail:
Title:  Journal of neurophysiology     Volume:  91     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-19     Completed Date:  2004-04-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1217-29     Citation Subset:  IM    
Affiliation:
Biomedical Engineering Department and the Neuroscience Institute, Northwestern University, Evanston, Illinois 60208, USA. psagls@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Cats
Electrophysiology
Entropy
Linear Models
Male
Membrane Potentials / physiology
Models, Neurological
Nonlinear Dynamics
Photic Stimulation
Reproducibility of Results
Retinal Ganglion Cells / physiology*
Synaptic Transmission / physiology*
Visual Perception / physiology*
Grant Support
ID/Acronym/Agency:
F32-EY-06908/EY/NEI NIH HHS; R01-EY-06669/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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