Document Detail


Information theory and the analysis of ligand-binding data.
MedLine Citation:
PMID:  2611338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The phenomenological principles of information theory are used in the analysis of ligand-binding phenomena in biological macromolecules. Information maps are constructed to visualize regions of ligand chemical potential with maximum amount of information and to devise suitable experimental strategies therefrom. Extensive simulation studies and analysis of experimental data also point out the properties of information used as a weighting procedure in nonlinear least-squares analyses.
Authors:
E Di Cera; F A Bassi; S J Gill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biophysical chemistry     Volume:  34     ISSN:  0301-4622     ISO Abbreviation:  Biophys. Chem.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1990-03-01     Completed Date:  1990-03-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0403171     Medline TA:  Biophys Chem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  19-28     Citation Subset:  IM    
Affiliation:
Istituto di Fisica, Università Cattolica, Roma, Italy.
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MeSH Terms
Descriptor/Qualifier:
Carbon Monoxide / metabolism
Hemoglobin A / metabolism
Information Theory*
Least-Squares Analysis
Ligands*
Macromolecular Substances*
Mathematics
Oxygen / metabolism
Thermodynamics
Grant Support
ID/Acronym/Agency:
HL22325/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Ligands; 0/Macromolecular Substances; 630-08-0/Carbon Monoxide; 7782-44-7/Oxygen; 9034-51-9/Hemoglobin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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