Document Detail


Influenza A virus receptors in the respiratory and intestinal tracts of pigeons.
MedLine Citation:
PMID:  19937510     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
To understand the basis of the resistance of pigeons to Asian lineage highly pathogenic avian influenza virus (HPAIV) subtype H5N1, we examined the presence of influenza virus receptors, sialic acids linked to galactose by an alpha-2,3 linkage (SAalpha2,3Gal) or by an alpha-2,6 linkage (SAalpha2,6Gal), in respiratory and intestinal tracts of pigeons and compared the distributions of N-acetylneuraminic and N-glycolylneuraminic acids in the trachea and intestines of pigeons and chickens. Results suggested that the epithelial surfaces of the larynx, trachea, bronchus, and bronchiole of pigeons contained abundant SAalpha2,6Gal with little or no SAalpha2,3Gal. In contrast, the epithelial surfaces of the pharynx, trachea, bronchus, and bronchiole of chickens contained mainly SAalpha2,3Gal, a well-recognized receptor for avian influenza viruses including H5N1 HPAIV. A similar distribution pattern of N-acetylneuraminic and N-glycolylneuraminic acids in the trachea and intestines of pigeons and chickens was observed. Overall, the results suggest that SAalpha2,6Gal is the major receptor in the pigeon airway, which may partly contribute to the resistance of pigeons to Asian lineage HPAIV subtype H5N1.
Authors:
Yuehuan Liu; Chunhua Han; Xiuqing Wang; Jian Lin; Ming Ma; Yuelong Shu; Jiao Zhou; Hanchun Yang; Qian Liang; Chaotan Guo; Junjie Zhu; Haitao Wei; Jingyi Zhao; Zhijun Ma; Jie Pan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Avian pathology : journal of the W.V.P.A     Volume:  38     ISSN:  1465-3338     ISO Abbreviation:  Avian Pathol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8210638     Medline TA:  Avian Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  263-6     Citation Subset:  IM    
Affiliation:
Institute of Animal and Husbandry Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, PR China. liuyuehuan@baafs.net.cn
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