Document Detail


Influenza virus infection of mice induces anorexia: comparison with endotoxin and interleukin-1 and the effects of indomethacin.
MedLine Citation:
PMID:  9164599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of infection of mice with influenza virus on ingestive behavior were assessed by both 22-h intake of food pellets, and intake of sweetened milk in a 30-minute access period. Infection with a lethal dose of virus resulted in losses in body weight as well as a reduction in food pellet intake. By contrast, infection with a sublethal dose of virus decreased body weight and food pellet intake to a lesser extent, but did not alter milk intake. Acute intraperitoneal injection of endotoxin (LPS, 0.3-5 micrograms), interleukin-1 alpha (IL-1 alpha, 50-100 ng) or IL-1 beta (100 ng) reduced milk intake, suggesting that the reduction of ingestive behavior may be associated with immune activation in general, and IL-1 in particular Pretreatment of the mice with the cyclooxygenase inhibitor, indomethacin (10 mg/kg SC) substantially attenuated, but did not completely reverse, the reduction in milk intake by LPS and IL-1. However, chronic treatment with indomethacin failed to alter the body weight or the intake of sweetened milk in influenza-infected mice, although there was some attenuation of the reduction in food intake. These results suggest that although IL-1 may play a role in the anorexia caused by influenza virus infection, it is not the only factor involved.
Authors:
A H Swiergiel; G N Smagin; A J Dunn
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  57     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:    1997 May-Jun
Date Detail:
Created Date:  1997-07-30     Completed Date:  1997-07-30     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  389-96     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Anorexia / etiology*
Cyclooxygenase Inhibitors / pharmacology*
Drug Evaluation, Preclinical
Feeding Behavior / drug effects
Indomethacin / pharmacology*
Interleukin-1 / antagonists & inhibitors*
Lethal Dose 50
Lipopolysaccharides / pharmacology*
Male
Mice
Mice, Inbred Strains
Motivation
Orthomyxoviridae Infections / complications*
Reward
Grant Support
ID/Acronym/Agency:
MH46261/MH/NIMH NIH HHS; NS25370/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Interleukin-1; 0/Lipopolysaccharides; XXE1CET956/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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