Document Detail


Influenza treatment and prophylaxis with neuraminidase inhibitors: a review.
MedLine Citation:
PMID:  24277988     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Influenza virus is a pathogen that causes morbidity and mortality worldwide. Whereas vaccination is important for prevention of disease, given its limitations, antiviral therapy is at the forefront of treatment and also plays a role in prevention. Currently, two classes of antiviral medications, the adamantanes and the neuraminidase inhibitors, are approved for treatment. Given the resistance patterns of circulating influenza, adamantanes are not recommended. Within the US, two neuraminidase inhibitors are currently approved for both treatment and prevention, while worldwide there are four available. In this review, we will briefly discuss the epidemiology and pathology of influenza and then discuss neuraminidase inhibitors: their mechanism of action, resistance, development, and future applications.
Authors:
Amanda Kamali; Mark Holodniy
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-11-19
Journal Detail:
Title:  Infection and drug resistance     Volume:  6     ISSN:  1178-6973     ISO Abbreviation:  Infect Drug Resist     Publication Date:  2013  
Date Detail:
Created Date:  2013-11-26     Completed Date:  2013-11-26     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  101550216     Medline TA:  Infect Drug Resist     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  187-98     Citation Subset:  -    
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