Document Detail

Influenza: response of T-cell lymphopenia to thymosin.
MedLine Citation:
PMID:  1083484     Owner:  NLM     Status:  MEDLINE    
Eighteen volunteers in tow study groups were inoculated with influenza A (H3N2) and their peripheral blood T, B and null cells enumerated at subsequent intervals. Infection with wild-type virus or with a live, attenuated virus vaccine markedly reduced the proportion and absolute number of T-cell rosettes 24 hours after inoculation. T-Cell depression preceded the onset of clinical illness in symptomatic subjects, continued during illness, and returned to normal with recovery. T-cell lymphopenia was most pronounced in volunteers infected with wild-type virus and was accompanied by an increase in null cells. Lymphocytes from six wild-virus recipients with T-cell leukopenia were incubated in vitro with a calfthymus extract (thymosin), significantly increasing the percentage of T rosettes in all six subjects (P less than 0.0001). These data indicate that influenza is accompanied by pronounced quantitative and functional changes in T cells.
M Scheinberg; N R Blacklow; A L Goldstein; T A Parrino; F B Rose; E S Cathcart
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  294     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1208-11     Citation Subset:  AIM; IM    
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MeSH Terms
B-Lymphocytes / immunology
Immune Adherence Reaction
Influenza, Human / blood,  immunology*
Leukocyte Count
Orthomyxoviridae / immunology
T-Lymphocytes / drug effects*,  immunology
Thymosin / pharmacology*
Thymus Extracts / pharmacology*
Reg. No./Substance:
0/Thymus Extracts; 61512-21-8/Thymosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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