| Influenza: response of T-cell lymphopenia to thymosin. | |
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MedLine Citation:
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PMID: 1083484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eighteen volunteers in tow study groups were inoculated with influenza A (H3N2) and their peripheral blood T, B and null cells enumerated at subsequent intervals. Infection with wild-type virus or with a live, attenuated virus vaccine markedly reduced the proportion and absolute number of T-cell rosettes 24 hours after inoculation. T-Cell depression preceded the onset of clinical illness in symptomatic subjects, continued during illness, and returned to normal with recovery. T-cell lymphopenia was most pronounced in volunteers infected with wild-type virus and was accompanied by an increase in null cells. Lymphocytes from six wild-virus recipients with T-cell leukopenia were incubated in vitro with a calfthymus extract (thymosin), significantly increasing the percentage of T rosettes in all six subjects (P less than 0.0001). These data indicate that influenza is accompanied by pronounced quantitative and functional changes in T cells. |
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Authors:
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M Scheinberg; N R Blacklow; A L Goldstein; T A Parrino; F B Rose; E S Cathcart |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The New England journal of medicine Volume: 294 ISSN: 0028-4793 ISO Abbreviation: N. Engl. J. Med. Publication Date: 1976 May |
Date Detail:
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Created Date: 1976-07-06 Completed Date: 1976-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1208-11 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult B-Lymphocytes / immunology Female Humans Immune Adherence Reaction Influenza, Human / blood, immunology* Leukocyte Count Male Orthomyxoviridae / immunology T-Lymphocytes / drug effects*, immunology Thymosin / pharmacology* Thymus Extracts / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Thymus Extracts; 61512-21-8/Thymosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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