Document Detail

Influenza: response of T-cell lymphopenia to thymosin.
MedLine Citation:
PMID:  1083484     Owner:  NLM     Status:  MEDLINE    
Eighteen volunteers in tow study groups were inoculated with influenza A (H3N2) and their peripheral blood T, B and null cells enumerated at subsequent intervals. Infection with wild-type virus or with a live, attenuated virus vaccine markedly reduced the proportion and absolute number of T-cell rosettes 24 hours after inoculation. T-Cell depression preceded the onset of clinical illness in symptomatic subjects, continued during illness, and returned to normal with recovery. T-cell lymphopenia was most pronounced in volunteers infected with wild-type virus and was accompanied by an increase in null cells. Lymphocytes from six wild-virus recipients with T-cell leukopenia were incubated in vitro with a calfthymus extract (thymosin), significantly increasing the percentage of T rosettes in all six subjects (P less than 0.0001). These data indicate that influenza is accompanied by pronounced quantitative and functional changes in T cells.
M Scheinberg; N R Blacklow; A L Goldstein; T A Parrino; F B Rose; E S Cathcart
Related Documents :
2904734 - Interaction between anti-influenza viral polymerase antibodies and rnp particles using ...
10338194 - Recruitment of apoptotic cysteine proteases (caspases) in influenza virus-induced cell ...
20327514 - Rapid laboratory diagnosis of an outbreak of influenza.
17008234 - Lack of correlation between nutritional status and seroprotection against influenza in ...
11440474 - Micronuclei and other nuclear lesions as genotoxicity indicators in rainbow trout oncor...
18176224 - Formation of in vitro murine cleft palate by abrogation of fibroblast growth factor sig...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  294     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1208-11     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
B-Lymphocytes / immunology
Immune Adherence Reaction
Influenza, Human / blood,  immunology*
Leukocyte Count
Orthomyxoviridae / immunology
T-Lymphocytes / drug effects*,  immunology
Thymosin / pharmacology*
Thymus Extracts / pharmacology*
Reg. No./Substance:
0/Thymus Extracts; 61512-21-8/Thymosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The variable pattern of circulating lymphocyte subpopulations in chronic lymphocytic leukemia.
Next Document:  Liver disease in alpha1-antitrypsin deficiency detected by screening of 200,000 infants.