Document Detail


Influenza: lessons from past pandemics, warnings from current incidents.
MedLine Citation:
PMID:  16064053     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent outbreaks of highly pathogenic avian influenza A virus infections (H5 and H7 subtypes) in poultry and in humans (through direct contact with infected birds) have had important economic repercussions and have raised concerns that a new influenza pandemic will occur in the near future. The eradication of pathogenic avian influenza viruses seems to be the most effective way to prevent influenza pandemics, although this strategy has not proven successful so far. Here, we review the molecular factors that contribute to the emergence of pandemic strains.
Authors:
Taisuke Horimoto; Yoshihiro Kawaoka
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Nature reviews. Microbiology     Volume:  3     ISSN:  1740-1526     ISO Abbreviation:  Nat. Rev. Microbiol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-02     Completed Date:  2005-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101190261     Medline TA:  Nat Rev Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  591-600     Citation Subset:  IM    
Affiliation:
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antiviral Agents / therapeutic use
Biological Markers / metabolism
Disease Outbreaks / prevention & control*
Humans
Influenza A virus / pathogenicity*,  physiology
Influenza Vaccines / therapeutic use
Influenza in Birds / epidemiology*,  prevention & control,  virology
Influenza, Human / epidemiology*,  prevention & control,  virology
Poultry
Virulence
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Biological Markers; 0/Influenza Vaccines

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