| Influenza A infection triggers thrombotic thrombocytopenic purpura by producing the anti-ADAMTS13 IgG inhibitor. | |
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MedLine Citation:
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PMID: 20371960 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 68-year-old Japanese woman infected with influenza A developed thrombotic thrombocytopenic purpura (TTP) 2 days after having a fever. Routine laboratory tests on admission suggested a diagnosis of disseminated intravascular coagulation. However, ADAMTS13 assays showed an extremely low level of plasma ADAMTS13 activity with a high titer of anti-ADAMTS13 inhibitor (IgG). Despite high-dose methylprednisolone therapy with daily plasma exchange for 3 consecutive days, the patient died of pulmonary congestion complicated by cardiac failure. Our experience here provides the first evidence that influenza A infection is sufficient to trigger TTP by producing the anti-ADAMTS13 IgG inhibitor. |
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Authors:
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Nobuharu Kosugi; Yuya Tsurutani; Ayami Isonishi; Yuji Hori; Masanori Matsumoto; Yoshihiro Fujimura |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-01 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 49 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 689-93 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Numazu City Hospital, Numazu. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ADAM Proteins
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antagonists & inhibitors*,
blood,
immunology Aged Antibodies, Anti-Idiotypic* / blood, immunology Female Humans Immunoglobulin G / blood, immunology Influenza A virus* Influenza, Human / blood, complications*, immunology Purpura, Thrombotic Thrombocytopenic / blood, etiology*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic; 0/Immunoglobulin G; 0/anti-IgG; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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