| Influenza B lineage circulation and hospitalisation rate in a subtropical city, Hong Kong, 2000-2010. | |
| | |
MedLine Citation:
|
PMID: 23074315 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background. A need for quadrivalent vaccines to cover both lineages of influenza B has been raised. Information on the circulation status of influenza B lineages, and the associated hospitalisation rates is important to assist evidence-based decision making. This retrospective study revealed the situation in a subtropical city over a 10-year period.Methods. Sequences of 268 influenza B isolates were analyzed to identify the circulating pool of virus lineages for each year. Hospital records and population census data were used to estimate annual age-specific hospitalisation rates.Results. Co-circulation with two influenza B lineages was found in 9 of the 10 years. Only in 6 of the 10 years had the vaccine strain successfully matched with the lineage that was found in >50% of the circulating pool. Six years were predominated by one lineage (occupying >80% of the circulating pool), and these years had higher (average, 1.4-fold) hospitalisation rates. Matching between vaccine and circulating lineage was achieved only in 2 of the 6 "predominated years". The Yamagata lineage accounted for most (5/6) of the "predominated years". Overall, 24% of influenza admissions were due to influenza B, and influenza B contributed to a higher proportion (41.9%) among children and young teenagers (5-14 years old).Conclusions. Co-circulation with two influenza B lineages is common in the subtropical region. To predict the next predominant lineage proves to be difficult. Influenza B accounts for a substantial fraction of influenza-associated hospitalisations, especially among children and young teenagers. Quadrivalent vaccines may improve the effectiveness of influenza vaccination programs. |
| | |
Authors:
|
Paul K S Chan; Martin C W Chan; Jo L K Cheung; Nelson Lee; Ting F Leung; Apple C M Yeung; Martin C S Wong; Karry L K Ngai; E Anthony S Nelson; David S C Hui |
Related Documents
:
|
13974075 - Live tissue-culture influenza vaccine. 20930705 - Influenza activity --- united states and worldwide, june 13-september 25, 2010. 18573295 - Confounding in evaluating the effectiveness of influenza vaccine. 18829805 - Influenza-associated pediatric mortality in the united states: increase of staphylococc... 12001045 - Induction of cross-reactive antibodies by immunization of healthy adults with types ia ... 16648945 - Evaluation of influenza vaccination in health-care workers, using rapid antigen detecti... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-16 |
Journal Detail:
|
Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: - ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Microbiology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems ...
Next Document: Suboptimal Adherence to Repeat Testing Recommendations for Men and Women With Positive Chlamydia Tes...