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Influenza B lineage circulation and hospitalisation rate in a subtropical city, Hong Kong, 2000-2010.
MedLine Citation:
PMID:  23074315     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background. A need for quadrivalent vaccines to cover both lineages of influenza B has been raised. Information on the circulation status of influenza B lineages, and the associated hospitalisation rates is important to assist evidence-based decision making. This retrospective study revealed the situation in a subtropical city over a 10-year period.Methods. Sequences of 268 influenza B isolates were analyzed to identify the circulating pool of virus lineages for each year. Hospital records and population census data were used to estimate annual age-specific hospitalisation rates.Results. Co-circulation with two influenza B lineages was found in 9 of the 10 years. Only in 6 of the 10 years had the vaccine strain successfully matched with the lineage that was found in >50% of the circulating pool. Six years were predominated by one lineage (occupying >80% of the circulating pool), and these years had higher (average, 1.4-fold) hospitalisation rates. Matching between vaccine and circulating lineage was achieved only in 2 of the 6 "predominated years". The Yamagata lineage accounted for most (5/6) of the "predominated years". Overall, 24% of influenza admissions were due to influenza B, and influenza B contributed to a higher proportion (41.9%) among children and young teenagers (5-14 years old).Conclusions. Co-circulation with two influenza B lineages is common in the subtropical region. To predict the next predominant lineage proves to be difficult. Influenza B accounts for a substantial fraction of influenza-associated hospitalisations, especially among children and young teenagers. Quadrivalent vaccines may improve the effectiveness of influenza vaccination programs.
Authors:
Paul K S Chan; Martin C W Chan; Jo L K Cheung; Nelson Lee; Ting F Leung; Apple C M Yeung; Martin C S Wong; Karry L K Ngai; E Anthony S Nelson; David S C Hui
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-16
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  -     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Microbiology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
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