| Influences of the sympatho-adrenal system on gastric motility and acid secretion and on gastroduodenal bicarbonate secretion in the cat. | |
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MedLine Citation:
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PMID: 2929368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experiments were performed on acutely vagotomized cats during chloralose anaesthesia. Gastric H+ and HCO3- secretions were calculated from the pH and PCO2 in a luminal perfusate. Gastric motility was reflected by changes in hydrostatic pressure within the luminal perfusion system ('intragastric pressure'). Duodenal HCO3- secretion was monitored by pH titration in situ. Animals with an intact sympatho-adrenal system (group 1) were compared with others subjected to splanchnicotomy (group 2), adrenal gland ligation (group 3), and splanchnicotomy plus adrenal gland ligation (group 4). Basal gastric H+ secretion, as well as vagally induced H+ secretory responses, did not differ significantly between groups. Basal gastric HCO3- secretion was lower in all groups with a manipulated sympatho-adrenal system compared to the intact controls. Vagally induced increases in gastric HCO3- secretion were enhanced in the splanchnicotomized groups (groups 2 and 4). Basal as well as vagally induced increases in intragastric pressure and duodenal HCO3- secretion were enhanced in animals subjected to splanchnicotomy, with or without simultaneous adrenal gland ligation (groups 2 and 4). Adrenal gland ligation per se had no such effects. The results suggest that the adrenal glands exert a stimulatory action on basal gastric HCO3- secretion. Basal intragastric pressure and basal duodenal HCO3- secretion are inhibited by post-ganglionic sympathetic neurons, not involving the adrenal glands. Also, vagal excitatory effects on gastric motility, as well as on gastric and duodenal HCO3- secretions, are inhibited by such a direct neural mechanism. |
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Authors:
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L Fändriks; C Jönson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 135 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-04-21 Completed Date: 1989-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 285-92 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Göteborg, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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physiology* Animals Bicarbonates / secretion* Cats Duodenum / secretion* Electric Stimulation Female Gastric Acid / secretion* Gastrointestinal Motility* Hydrostatic Pressure Male Splanchnic Nerves / physiology Sympathetic Nervous System / physiology* Vagotomy |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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