| Influences of selective sympathetic denervation on coronary reactive hyperemia in conscious dogs. | |
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MedLine Citation:
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PMID: 7252049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mongrel dogs were chronically instrumented to measure left circumflex coronary flow, arterial pressure, left atrial pressure, ECG, heart rate and in some cases, left ventricular pressure or cardiac output. A cuff type occluder was placed distal to the flow probe. Total occlusion of the left circumflex coronary artery for one minute in unsedated, resting dogs produced reactive hyperemia with an average replacement/deficit ratio of 2.63/1. In 11 dogs, sympathetic influences were investigated by chronic surgical cardiac sympathectomy. Surgical section of all ansae subclaviae responses from 2.61/1 to 1.67/1 (P less than 0.001). Left sympathectomy alone had no effect on the replacement/deficit ratio whereas selective right sympathectomy reduced it from 2.25/1 to 1.38/1. Pharmacological blockade was used to determine beta-receptor involvement in the responses. In 9 intact dogs practolol (10 mg/kg) reduced the reactive hyperemia ratio by 12% (P less than 0.05). Propranolol (1 mg/kg) further reduced this ratio by 30% (P less than 0.001). Our results suggest that sympathetic beta influences work primarily through the right cardiac sympathetic nerves. Also, the magnitude of the response appears to be due, in part, to increased metabolic activity associated with myocardial beta 1-receptors and heart rate increase as well as active vasodilation through beta 2-receptors. |
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Authors:
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D F Peterson; V S Bishop |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the autonomic nervous system Volume: 2 ISSN: 0165-1838 ISO Abbreviation: J. Auton. Nerv. Syst. Publication Date: 1980 May |
Date Detail:
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Created Date: 1981-09-25 Completed Date: 1981-09-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8003419 Medline TA: J Auton Nerv Syst Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 47-59 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Fibers
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physiology* Animals Coronary Circulation* / drug effects Coronary Vessels / innervation* Denervation Dogs Efferent Pathways / physiology Hemodynamics / drug effects Practolol / pharmacology Propranolol / pharmacology Reflex / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL 12415/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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525-66-6/Propranolol; 6673-35-4/Practolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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