Document Detail

Influences on seizure activity in pregnant women with epilepsy.
MedLine Citation:
PMID:  19328868     Owner:  NLM     Status:  MEDLINE    
This study evaluated whether referral to a specialized epilepsy clinic prior to pregnancy influences seizure activity during pregnancy. In addition, folic acid supplementation prior to pregnancy as a marker of intent to conceive was used to evaluate whether the use of folic acid at the time of conception correlates with the risk of seizure deterioration in pregnancy. The study population consisted of patients who had been followed in a specialized epilepsy clinic before conception (group 1, n=46) and patients who were referred to the clinic after the pregnancy was recognized (group 2, n=44). Seizure deterioration was significantly lower in group 1 than in group 2: 9% versus 32% (P<0.01). In addition, the likelihood of having taken folic acid supplements was significantly higher in group 1 (P<0.001). With some methodological limitations taken into account, it is concluded that women followed in a specialized epilepsy clinic have a lower risk of seizure deterioration during pregnancy compared with those referred after conception.
Anne Sabers
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Publication Detail:
Type:  Journal Article     Date:  2009-04-26
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  15     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-21     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230-4     Citation Subset:  IM    
The Epilepsy Clinic, Glostrup University Hospital, Ndr. Ringvej, Glostrup DK-2600, Denmark.
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MeSH Terms
Anticonvulsants / therapeutic use
Dietary Supplements
Epilepsy / complications*,  psychology,  therapy
Folic Acid / administration & dosage
Follow-Up Studies
Pregnancy Complications / physiopathology*,  prevention & control,  psychology
Referral and Consultation
Risk Factors
Seizures / etiology*,  prevention & control
Women's Health
Young Adult
Reg. No./Substance:
0/Anticonvulsants; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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