Document Detail


Influences of rewarding and aversive outcomes on activity in macaque lateral prefrontal cortex.
MedLine Citation:
PMID:  16982429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Both appetitive and aversive outcomes can reinforce animal behavior. It is not clear, however, whether the opposing kinds of reinforcers are processed by specific or common neural mechanisms. To investigate this issue, we studied macaque monkeys that performed a memory-guided saccade task for three different outcomes, namely delivery of liquid reward, avoidance of air puff, and feedback sound only. Animals performed the task best in rewarded trials, intermediately in aversive trials, and worst in sound-only trials. Most task-related activity in lateral prefrontal cortex was differentially influenced by the reinforcers. Aversive avoidance had clear effects on some prefrontal neurons, although the effects of rewards were more common. We also observed neurons modulated by both positive and negative reinforcers, reflecting reinforcement or attentional processes. Our results demonstrate that information about positive and negative reinforcers is processed differentially in prefrontal cortex, which could contribute to the role of this structure in goal-directed behavior.
Authors:
Shunsuke Kobayashi; Kensaku Nomoto; Masataka Watanabe; Okihide Hikosaka; Wolfram Schultz; Masamichi Sakagami
Related Documents :
22988289 - A role of protein degradation in memory consolidation after initial learning and extinc...
15892889 - Hippocampal lesions facilitate instrumental learning with delayed reinforcement but ind...
24815889 - Allergic rhinitis is a risk factor for traffic safety.
24233429 - Effects of accuracy feedback versus monetary contingency on arousal in high and low fre...
24279229 - Cognition at altitude: impairment in executive and memory processes under hypoxic condi...
23014569 - A flavonol present in cocoa [(-)epicatechin] enhances snail memory.
12025879 - The effect of virtual reality cognitive training for attention enhancement.
24065899 - Erratum: targeting the endocannabinoid system to treat haunting traumatic memories.
11571039 - Memory for events and their spatial context: models and experiments.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  51     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-19     Completed Date:  2006-11-07     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  861-70     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Appetitive Behavior / physiology
Behavior, Animal / physiology
Conditioning, Operant / physiology*
Cues
Functional Laterality / physiology
Macaca / physiology*
Male
Memory / physiology
Models, Neurological
Neurons / physiology
Prefrontal Cortex / cytology,  physiology*
Psychomotor Performance / physiology
Reward*
Grant Support
ID/Acronym/Agency:
095495//Wellcome Trust; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Temporal processing and adaptation in the songbird auditory forebrain.
Next Document:  Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activit...