Document Detail

Influences of rewarding and aversive outcomes on activity in macaque lateral prefrontal cortex.
MedLine Citation:
PMID:  16982429     Owner:  NLM     Status:  MEDLINE    
Both appetitive and aversive outcomes can reinforce animal behavior. It is not clear, however, whether the opposing kinds of reinforcers are processed by specific or common neural mechanisms. To investigate this issue, we studied macaque monkeys that performed a memory-guided saccade task for three different outcomes, namely delivery of liquid reward, avoidance of air puff, and feedback sound only. Animals performed the task best in rewarded trials, intermediately in aversive trials, and worst in sound-only trials. Most task-related activity in lateral prefrontal cortex was differentially influenced by the reinforcers. Aversive avoidance had clear effects on some prefrontal neurons, although the effects of rewards were more common. We also observed neurons modulated by both positive and negative reinforcers, reflecting reinforcement or attentional processes. Our results demonstrate that information about positive and negative reinforcers is processed differentially in prefrontal cortex, which could contribute to the role of this structure in goal-directed behavior.
Shunsuke Kobayashi; Kensaku Nomoto; Masataka Watanabe; Okihide Hikosaka; Wolfram Schultz; Masamichi Sakagami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  51     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-19     Completed Date:  2006-11-07     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  861-70     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Appetitive Behavior / physiology
Behavior, Animal / physiology
Conditioning, Operant / physiology*
Functional Laterality / physiology
Macaca / physiology*
Memory / physiology
Models, Neurological
Neurons / physiology
Prefrontal Cortex / cytology,  physiology*
Psychomotor Performance / physiology
Grant Support
095495//Wellcome Trust; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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