Document Detail

Influences of normobaric hypoxia training on metabolic risk markers in human subjects.
MedLine Citation:
PMID:  18845972     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Endurance exercise and hypoxia regulate pathways that are crucial to glucose and lipid metabolism. We hypothesized that training under hypoxia results in similar or even greater metabolic improvement compared with exercise under normoxia at a lower workload. METHODS: We randomly assigned 20 healthy men to single blind training under hypoxia (FiO2 = 15%) or normoxia (FiO2 = 21%). Subjects trained thrice weekly for 60 min over a 4-wk period at a heart rate measured at 3 mmol x L(-1) lactate during pretraining exercise testing. Before and after the training period, we determined body composition, venous blood parameters, oral glucose tolerance, and blood pressure. Furthermore, we assessed oxygen uptake (VO2), lactate, and respiratory quotient, and heart rate (HR) during incremental exercise testing, both in hypoxia and in normoxia. Training workload was 1.39 +/- 0.2 W x kg(-1) in the hypoxia and 1.67 +/- 0.15 W x kg(-1) in the normoxia group (P< 0.001) with an identical training heart rate in both groups. RESULTS: Exercise capacity improved similarly with both interventions. With hypoxia training, body fat content, triglycerides, HOMA-Index, fasting insulin (P < 0.05), and area under the curve for insulin (P < 0.01) during the oral glucose tolerance test improved more than with the training in normoxia. We did not observe major changes in adipokine measurements. CONCLUSION: Endurance training in hypoxia over a 4-wk period elicits a similar or even better response in terms of cardiovascular and metabolic risk factors than endurance exercise in normoxia. The fact that workload and, therefore, mechanic strain can be reduced in hypoxia could be particularly beneficial in obese patients and in patients with orthopedic conditions.
Sven Haufe; Susanne Wiesner; Stefan Engeli; Friedrich C Luft; Jens Jordan
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  40     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2009-05-12     Completed Date:  2009-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1939-44     Citation Subset:  IM; S    
Franz Volhard Clinical Research Center, Medical Faculty of the Charité, Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptation, Physiological / physiology
Adipokines / analysis
Anoxia / physiopathology*
Glucose Tolerance Test
Metabolism / physiology*
Oxygen / blood
Physical Exertion / physiology*
Physical Fitness / physiology
Risk Factors
Single-Blind Method
Young Adult
Reg. No./Substance:
0/Adipokines; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Age-related changes in aerobic capacity in individuals with mental retardation: a 20-yr review.
Next Document:  Potential benefit from an H1-receptor antagonist on postexercise syncope in the heat.