| Influences of melatonin on human circadian rhythms. | |
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MedLine Citation:
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PMID: 9095379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Administration of melatonin is useful in the treatment of desynchronized conditions. The mechanisms through which melatonin exerts its effect are not completely clear. Melatonin exerts direct effects on several biological functions, such as the regulation of body temperature, but there is no proof that these actions are important in the indirect regulation of main pacemaker activity. By contrast, it is very likely that melatonin exerts direct effects on circadian clocks, and that depending on the time of its administration/presence, it antagonizes or promotes the phase-shifting effects exerted by light. It is possible that melatonin regulates its own secretion and that its prolonged or shortened secretion in the period of the night-day transition is responsible for the lengthening or shortening, respectively, of the nocturnal melatonin rise. This possibility that needs to be confirmed by extensive studies may represent a physiological mechanism through which photoperiodic information is more rapidly and efficiently transformed by melatonin in a circadian signal to all the body. |
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Authors:
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A Cagnacci |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Chronobiology international Volume: 14 ISSN: 0742-0528 ISO Abbreviation: Chronobiol. Int. Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-06-09 Completed Date: 1997-06-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8501362 Medline TA: Chronobiol Int Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 205-20 Citation Subset: IM |
Affiliation:
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Istituto di Fisiopatologia della Riproduzione Umana, Università di Modena, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects Circadian Rhythm / drug effects, physiology* Humans Light Melatonin / pharmacology, physiology*, therapeutic use Models, Neurological Neurons / physiology Suprachiasmatic Nucleus / physiology* |
| Chemical | |
Reg. No./Substance:
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73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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