| Influences of an analog of the neuropeptide ACTH 4--9 on mentally retarded adults. | |
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MedLine Citation:
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PMID: 217271 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a double-blind procedure, 24 mentally retarded adults received 0 mg, 5mg, or 20 mg of an analog of the neuropeptide ACTH 4--9. Following treatment with peptide, the subjects were given the Trails B Test (from the Halstead-Reitan Neuropsychological Battery), the Peabody Picture Vocabulary test, the Benton Visual Retention Test, a concept-formation task, and a standard orienting sequence. The results of the behavioral tests suggested that attentional processes were enhanced in subjects treated with the peptide. The present study, in conjunction with another investigation using the neuropeptide ACTH/MSH 4--10 (Sandman, George, Walker, Nolan & Kastin, 1976), indicates that attentional deficits in mentally retarded adults, traditionally assumed to be irreversible, may be influenced by treatment with fragments of the neuropeptides ACTH and MSH. |
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Authors:
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B B Walker; C A Sandman |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of mental deficiency Volume: 83 ISSN: 0002-9351 ISO Abbreviation: Am J Ment Defic Publication Date: 1979 Jan |
Date Detail:
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Created Date: 1979-04-25 Completed Date: 1979-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372647 Medline TA: Am J Ment Defic Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 346-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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analogs & derivatives*,
therapeutic use Adult Attention / drug effects* Concept Formation / drug effects Double-Blind Method Female Humans Male Memory / drug effects Mental Retardation / drug therapy* Middle Aged Peptide Fragments / therapeutic use* Psychological Tests Reversal Learning / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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