Document Detail

Influences of aortic motion and curvature on vessel expansion in murine experimental aneurysms.
MedLine Citation:
PMID:  21071686     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To quantitatively compare aortic curvature and motion with resulting aneurysm location, direction of expansion, and pathophysiological features in experimental abdominal aortic aneurysms (AAAs).
METHODS AND RESULTS: MRI was performed at 4.7 T with the following parameters: (1) 3D acquisition for vessel geometry and (2) 2D cardiac-gated acquisition to quantify luminal motion. Male 24-week-old mice were imaged before and after AAA formation induced by angiotensin II (AngII)-filled osmotic pump implantation or infusion of elastase. AngII-induced AAAs formed near the location of maximum abdominal aortic curvature, and the leftward direction of expansion was correlated with the direction of suprarenal aortic motion. Elastase-induced AAAs formed in a region of low vessel curvature and had no repeatable direction of expansion. AngII significantly increased mean blood pressure (22.7 mm Hg, P<0.05), whereas both models showed a significant 2-fold decrease in aortic cyclic strain (P<0.05). Differences in patterns of elastin degradation and localization of fluorescent signal from protease-activated probes were also observed.
CONCLUSIONS: The direction of AngII aneurysm expansion correlated with the direction of motion, medial elastin dissection, and adventitial remodeling. Anterior infrarenal aortic motion correlated with medial elastin degradation in elastase-induced aneurysms. Results from both models suggest a relationship between aneurysm pathological features and aortic geometry and motion.
Craig J Goergen; Junya Azuma; Kyla N Barr; Lars Magdefessel; Dara Y Kallop; Alvin Gogineni; Amarjeet Grewall; Robby M Weimer; Andrew J Connolly; Ronald L Dalman; Charles A Taylor; Philip S Tsao; Joan M Greve
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-11-11
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  31     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-20     Completed Date:  2011-03-14     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-9     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / adverse effects*
Aorta, Abdominal / pathology*,  physiopathology*,  ultrasonography
Aortic Aneurysm, Abdominal / chemically induced*,  pathology,  physiopathology*
Biomechanical Phenomena
Blood Pressure / physiology
Disease Progression
Elastin / metabolism
Hypertension / physiopathology
Magnetic Resonance Imaging
Mice, Inbred C57BL
Mice, Knockout
Models, Animal
Models, Cardiovascular
Grant Support
1 P50 HL 83800-04/HL/NHLBI NIH HHS; P50 HL083800/HL/NHLBI NIH HHS; P50 HL083800-04/HL/NHLBI NIH HHS
Reg. No./Substance:
11128-99-7/Angiotensin II; 9007-58-3/Elastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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