| Influence of xantinole nicotinic acid on cutaneous microcirculation in patients with coronary artery disease and hyperlipoproteinemia. | |
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MedLine Citation:
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PMID: 18503137 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Xantinole nicotinic acid (NA) dose dependently lowers plasma levels of atherogenic lipoproteins and increases blood flow through vasodilation. The aim of this study was to evaluate the effect of NA on cutaneous microcirculation in patients with coronary artery disease and hyperlipidemia. In this open pilot study, five men and three women (74.2+/-9.1 yrs; 81.4+/-7.9 kg; 171.6+/-7.0 cm) with angiographically proven coronary artery disease and hyperlipidemia were included. Nailfold capillary microscopy was used for measurements of erythrocyte velocities at rest and after three minutes of ischemia, before and one hour after intake of 1000 mg of NA. The blood pressure (120+/-12/73+/-8 mmHg vs. 113+/-10/72+/-5 mmHg; p=0.19/0.83) and the heart rate (72+/-8/min vs. 70+/-7/min; p=0.38) remained unchanged. The mean capillary red blood cell velocity at rest (v(RBC); 0.27+/-0.23 mm/s vs. 0.32+/-0.18 mm/s; p=0.089) and the time to maximal post ischemia erythrocyte velocity (t(peak); 21.0+/-7.9 s vs. 24.3+/-15.5 s; p=0.49) did not change. The maximal post ischemic erythrocyte velocity (v(maxRBC); 0.93+/-0.33 mm/s vs. 1.19+/-0.19 mm/s; p=0.0096) raised slightly but significantly, the duration of post-ischemia hyperemia (DpH; 101+/-16 s vs. 127+/-15 s; p=0.0005) increased markedly. One patient reported about flush in the whole body. The administration of 1000 mg of NA resulted in a significant improvement of the cutaneous microcirculation in patients with coronary artery disease and hyperlipidemia. |
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Authors:
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B Leithäuser; U Gerk; C Mrowietz; F Jung; J-W Park |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical hemorheology and microcirculation Volume: 39 ISSN: 1386-0291 ISO Abbreviation: Clin. Hemorheol. Microcirc. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-05-26 Completed Date: 2008-08-20 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 9709206 Medline TA: Clin Hemorheol Microcirc Country: Netherlands |
Other Details:
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Languages: eng Pagination: 287-92 Citation Subset: IM |
Affiliation:
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Clinic for Angiology, Hannover, Germany. boris.leithaeuser@arcor.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure Capillaries / metabolism Coronary Artery Disease / blood*, drug therapy* Female Heart Rate Humans Hyperlipoproteinemias / blood*, drug therapy* Lipoproteins / metabolism Male Microcirculation* Middle Aged Niacin / chemistry, pharmacology* Pilot Projects Skin / blood supply* |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins; 59-67-6/Niacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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