Document Detail


Influence of xamoterol, a partial beta 1-selective agonist, on physical performance capacity and cardiocirculatory, metabolic and hormonal parameters.
MedLine Citation:
PMID:  2899509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a double-blind, random, cross-over study, 14 healthy male volunteers received xamoterol 200 mg (Corwin; C) twice daily or placebo (P) for two seven-day medication periods to investigate effects on physical performance, cardiocirculatory parameters, metabolism and hormone levels during exercise. An oral glucose tolerance test (OGTT) was also done. C showed a positive inotropic effect up to an exercise intensity of 100 W, corresponding to a heart rate of about 100 beats.min-1. Chronotropic regulation of the heart remained unchanged, but the increase in systolic blood pressure was more pronounced and the catecholamines behaved as after P. From 150 W onwards, C exhibited beta-blocking properties; heart rate was reduced by up to 8 beats.min-1; systolic blood pressure remained unchanged; and the catecholamines showed a more pronounced increase than after P. Diastolic blood pressure behaved almost identically under all test conditions. With the exception of a slightly increased level of free fatty acids at rest, the parameters of physical performance, lipid and carbohydrate metabolism and the hormone levels under all conditions after C showed similar behaviour to that after as P. The findings indicate that physical performance capacity, cardiocirculatory system, metabolism and hormones were not negatively influenced by C.
Authors:
T Kullmer; W Kindermann; A Urhausen; M Hess
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  34     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-09-06     Completed Date:  1988-09-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  255-62     Citation Subset:  IM    
Affiliation:
Department of Sports- and Performance Medicine, University of Saarland, Saarbrücken, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / pharmacology*
Adult
Blood Glucose / metabolism
Epinephrine / blood
Glucose Tolerance Test
Heart Rate / drug effects
Hemodynamics / drug effects*
Hormones / blood*
Humans
Male
Physical Exertion
Potassium / blood
Propanolamines / pharmacology*
Psychomotor Performance / drug effects*
Time Factors
Triglycerides / blood
Xamoterol
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Blood Glucose; 0/Hormones; 0/Propanolamines; 0/Triglycerides; 51-43-4/Epinephrine; 7440-09-7/Potassium; 81801-12-9/Xamoterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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