Document Detail

Influence of volume replacement with colloids versus crystalloids in neonates on venoarterial extracorporeal membrane oxygenation on fluid retention, fluid balance, and ECMO runtime.
MedLine Citation:
PMID:  16340372     Owner:  NLM     Status:  MEDLINE    
In this retrospective study, we compared the effects of colloid versus crystalloid fluid replacement on the clinical signs of capillary leakage syndrome in 30 neonates with pulmonary hypertension due to meconium aspiration syndrome on venoarterial membrane oxygenation (VA-ECMO). Before 2000, 15 neonates received volume replacement with a pasteurized plasma protein solution (3.8% albumin); after 2000, 15 neonates received normal saline. Patient characteristics and pre-ECMO values did not differ between the two groups. Total fluid balance was also equal. Diuretic use was significantly higher in the colloid group (p < 0.001). The chest wall soft-tissue index was significantly higher in the crystalloid group (p < 0.005), as were the ventilator settings at the end of the ECMO runtime (p < 0.05). Serum colloid osmotic pressure, albumin, urea nitrogen, and creatinine were significantly higher in the colloid group (p < 0.0001, < 0.0001, < 0.001, and < 0.05, respectively). Duration of VA-ECMO, of artificial ventilation after ECMO treatment, and the mortality rate did not differ between the two groups. We conclude that volume replacement with crystalloids in neonates on VA-ECMO aggravated the edema in a preexisting situation of capillary leakage syndrome, whereas volume replacement with colloids could impair the kidney function.
Sabine L Vrancken; Arno Fvan Heijst; Miranda Zegers; Frans Hvan der Staak; K Djien Liem; Arno F van Heijst; Frans H van der Staak
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  51     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  808-12     Citation Subset:  IM    
Department of Paediatrics, Division of Neonatology, Radboud University Medical Centre, Nijmegen, the Netherlands.
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MeSH Terms
Capillary Leak Syndrome / etiology,  therapy
Extracorporeal Membrane Oxygenation / adverse effects,  methods*
Fluid Therapy / adverse effects,  methods*
Hypertension, Pulmonary / etiology,  therapy
Infant, Newborn
Meconium Aspiration Syndrome / therapy
Retrospective Studies
Time Factors
Water-Electrolyte Balance
Reg. No./Substance:

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