Document Detail

Influence of volume expansion on hemodynamic effects of atrial natriuretic factor in rabbits.
MedLine Citation:
PMID:  2522285     Owner:  NLM     Status:  MEDLINE    
We investigated the influence of acute volume expansion on the hemodynamic and renal responses to the constant infusion of atrial natriuretic factor (ANF) (alpha-human ANP, 2 micrograms/kg bolus, 0.2 in rabbits anesthetized with ketamine and acepromazine. The effects of the peptide were evaluated in 12 euvolemic rabbits and in 15 rabbits during the steady-state phase of volume expansion (0.9% NaCl 4.5 ml/min for 60 min). In the euvolemic animals, ANF caused an increase in natriuresis and a reduction in blood pressure (BP), which was associated with a decrease in cardiac output (CO), stroke volume (SV), and no significant changes in central venous pressure (CVP), peripheral hematocrit (Hct), and heart rate (HR). When the peptide was infused in the volume-expanded animals, the effects of ANF on BP and HR were comparable with those observed in the euvolemic animals. However, in these animals the ANF-induced changes in CO, SV, CVP, and Hct were significantly greater than those observed in the euvolemic group. In addition, the percent increases in diuresis and natriuresis were significantly smaller than those obtained in the euvolemic animals. In conclusion, volume expansion with saline potentiates the effects of ANF on systemic hemodynamics and blood volume.
M Volpe; A Cuocolo; F Vecchione; G Lembo; S Pignalosa; M Condorelli; B Trimarco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  256     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-04-12     Completed Date:  1989-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H852-8     Citation Subset:  IM    
Istituto di Clinica Medica, Facoltà di Medicina, Università di Napoli, Naples, Italy.
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MeSH Terms
Atrial Natriuretic Factor / blood,  pharmacology*
Blood Pressure / drug effects
Blood Volume*
Cardiac Output / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Reference Values
Sodium Chloride / pharmacology
Stroke Volume / drug effects
Reg. No./Substance:
7647-14-5/Sodium Chloride; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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