| Influence of vitamin A palmitate on the growth of regenerating Triturus alpestris forelimbs. | |
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MedLine Citation:
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PMID: 3196784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this investigation was to analyse the effects of vitamin A palmitate orally administered to young postmetamorphic Triturus alpestris on the growth of regenerates. Vitamin A was administered for 4, 7, 11 and 14 days after amputation at the middle of the right zeugopod. Growth of regenerates was evaluated on the basis of external size measurements and blastema cell proliferation. Calculation of the percentages of cells in each cell-cycle phase and estimation of mitotic indices during the period of drug administration were performed by microdensitometric scanning of Feulgen-stained nuclei and counting of chromosome configurations, respectively. Vitamin A was found to induce polyploidism, to enhance transition from G1- to S-phase cell nuceli, to prolong the duration of G2-phase to the detriment of S-phase and to promote mitotic activity in the mesenchyme cells. In accordance with the above, an acceleration in the growth rates of treated blastemas with respect to controls was observed. |
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Authors:
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S Koussoulakos; H J Anton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological structures and morphogenesis Volume: 1 ISSN: 0989-8972 ISO Abbreviation: Biol Struct Morphog Publication Date: 1988 |
Date Detail:
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Created Date: 1989-01-17 Completed Date: 1989-01-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8807439 Medline TA: Biol Struct Morphog Country: FRANCE |
Other Details:
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Languages: eng Pagination: 124-9 Citation Subset: IM |
Affiliation:
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University of Athens, Zoological Laboratory, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division Forelimb / cytology, physiology* Regeneration / drug effects* Time Factors Triturus / physiology* Vitamin A / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
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11103-57-4/Vitamin A; 79-81-2/retinol palmitate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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