Document Detail


Influence of the vitamin D plasma level and vitamin D-related genetic polymorphisms on the immune status of patients with type 1 diabetes: a pilot study.
MedLine Citation:
PMID:  23286944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin D (VD) has been implicated in type 1 diabetes (T1D) by genetic and epidemiological studies. Individuals living in regions with low sunlight exposure have an increased T1D risk and VD supplementation reduced the risk in human individuals and mouse models. One possibility of how VD influences the pathogenesis of T1D is its immunomodulatory effect on dendritic cells (DC), which then preferentially activate regulatory T cells (T(regs) ). In the present pilot study, we collected blood samples from a small cohort of patients with T1D at baseline and months 6 and 12. VD-deficient patients were advised to supplement with 1000 IU/day VD. We found a considerable variation in the VD plasma level at baseline and follow-up. However, with higher VD plasma levels, a lower frequency of interleukin (IL)-4-producing CD8 T cells was observed. We further performed a comprehensive genotyping of 13 VD-related polymorphisms and found an association between VD plasma level and the genotype of the VD binding protein (DBP). The frequency of DC and T cell subsets was variable in patients of all subgroups and in individual patients over time. Nevertheless, we found some significant associations, including the 1,25-dihydroxyvitamin D(3) hydroxylase (CYP27B1) genotype with the frequency of DC subtypes. In summary, our preliminary results indicate only a limited influence of the VD plasma level on the immune balance in patients with T1D. Nevertheless, our pilot study provides a basis for a follow-up study with a larger cohort of patients.
Authors:
K Rose; M Penna-Martinez; E Klahold; D Kärger; F Shoghi; H Kahles; M Bayer; E Hintermann; J M Pfeilschifter; K Badenhoop; E Ramos-Lopez; U Christen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  171     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-03-12     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  171-85     Citation Subset:  IM    
Copyright Information:
© 2012 British Society for Immunology.
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MeSH Terms
Descriptor/Qualifier:
25-Hydroxyvitamin D3 1-alpha-Hydroxylase / genetics
Animals
CD8-Positive T-Lymphocytes / immunology*
Cell Proliferation
Cells, Cultured
DNA Mutational Analysis
DNA-Binding Proteins / genetics
Dendritic Cells / immunology*
Diabetes Mellitus, Type 1 / diagnosis,  genetics,  immunology*
Follow-Up Studies
Genetic Predisposition to Disease
Humans
Interleukin-4 / secretion
Lymphocyte Activation / genetics
Mice
Middle Aged
Pilot Projects
Polymorphism, Genetic
T-Lymphocytes, Regulatory / immunology*
Transcription Factors / genetics
Vitamin D / blood*
Chemical
Reg. No./Substance:
0/DBP protein, human; 0/DNA-Binding Proteins; 0/Transcription Factors; 1406-16-2/Vitamin D; 207137-56-2/Interleukin-4; EC 1.14.-/25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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