Document Detail


Influence of the viscosity of iodixanol on medullary and cortical blood flow in the rat kidney: a potential cause of Nephrotoxicity.
MedLine Citation:
PMID:  10513679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to investigate the effects of four iodinated contrast media on cortical, inner medullary and outer medullary blood flow in the rat kidney by using laser-Doppler flowmetry. The high-osmolar contrast medium diatrizoate did not significantly modify medullary perfusion but moderately decreased the cortical blood flow when injected at a dose of 1600 mg iodine kg(-1). Similar effects were obtained with the low-osmolar contrast media ioxaglate and iobitridol. In contrast, the new iso-osmolar contrast medium iodixanol induced a dose-dependent reduction of perfusion in all regions tested. This effect was accompanied by concomitant hypotension. The reduction of inner medullary and cortical blood flow induced by iodixanol was partially alleviated by heating the solution prior to injection and subsequently reducing its viscosity. In the outer medulla, however, this procedure did not improve blood flow. These results suggest that lowering the viscosity may palliate the harmful effects of iodixanol on the inner medulla and cortex, but may not protect the outer medulla from hypoxic injury.
Authors:
E Lancelot; J M Idée; V Couturier; V Vazin; C Corot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  19     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:    1999 Sep-Oct
Date Detail:
Created Date:  1999-10-29     Completed Date:  1999-10-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  341-6     Citation Subset:  IM    
Affiliation:
Guerbet, Research Division, F-95943 Roissy Charles de Gaulle, France. lanceloe@guerbet-group.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Contrast Media / chemistry,  pharmacology*,  toxicity
Diatrizoate / pharmacology
Dose-Response Relationship, Drug
Hemodynamics / drug effects
Iohexol / analogs & derivatives,  pharmacology
Ioxaglic Acid / pharmacology
Kidney / drug effects,  physiology
Kidney Cortex / blood supply*
Kidney Diseases / chemically induced,  physiopathology
Kidney Medulla / blood supply*
Male
Rats
Rats, Inbred Lew
Regional Blood Flow / drug effects
Renal Circulation / drug effects*
Triiodobenzoic Acids / chemistry,  pharmacology*,  toxicity
Viscosity
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Triiodobenzoic Acids; 0/iobitridol; 117-96-4/Diatrizoate; 59017-64-0/Ioxaglic Acid; 66108-95-0/Iohexol; 92339-11-2/iodixanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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