Document Detail


Influence of verteporfin photodynamic therapy on inflammation in human choroidal neovascular membranes secondary to age-related macular degeneration.
MedLine Citation:
PMID:  17621180     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To examine the short- and long-term consequences of verteporfin photodynamic therapy (PDT) on inflammation with regard to infiltration of macrophages and leukocytes and expression of thy-1 in human choroidal neovascularization membranes (CNV) secondary to age-related macular degeneration (AMD). METHODS: Retrospective review of an interventional case series of 43 patients who underwent removal of CNV. Twenty patients were treated with PDT 3 to 246 days preoperatively. Twenty-three CNV without previous treatment were used as control. CNV were stained for CD34, CD105, cytokeratin 18, Ki-67, thy-1, an endothelial cell glycoprotein known to be upregulated only by inflammatory cytokines, CD68 (macrophages), and CD45 (common leukocyte antigen). RESULTS: Specimens treated by PDT 3 days previously showed significantly reduced endothelial thy-1 expression (P = 0.008), leukocyte (P=0.04) and macrophage (P=0.0063) infiltration, and proliferative activity (P=0.02) compared to control CNV. Specimens at longer intervals after PDT, in contrast, disclosed a significantly increased expression of thy-1 (P=0.004), infiltration with leukocytes (P=0.044) and macrophages (P=0.01), and proliferative activity (P=0.03) compared to CNV excised 3 days after PDT. CONCLUSIONS: The rebound effect after PDT seems to be based on an inflammatory response that contributes to enhanced proliferation. These data support the need for an anti-inflammatory therapy as adjuvant to PDT.
Authors:
Olcay Tatar; Annemarie Adam; Kei Shinoda; Efdal Yoeruek; Peter Szurman; Silvia Bopp; Claus Eckardt; Karl Ulrich Bartz-Schmidt; Salvatore Grisanti
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  27     ISSN:  0275-004X     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:    2007 Jul-Aug
Date Detail:
Created Date:  2007-07-10     Completed Date:  2007-08-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  United States    
Other Details:
Languages:  eng     Pagination:  713-23     Citation Subset:  IM    
Affiliation:
University Eye Hospital at the Center for Ophthalmology, Eberhard-Karls University Tuebingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Antigens, CD / metabolism
Antigens, CD34 / metabolism
Antigens, CD45 / metabolism
Antigens, Differentiation, Myelomonocytic / metabolism
Antigens, Thy-1 / metabolism
Choroidal Neovascularization / drug therapy*,  etiology,  pathology
Choroiditis / drug therapy*,  etiology,  pathology
Female
Humans
Immunoenzyme Techniques
Keratin-18 / metabolism
Leukocytes / metabolism,  pathology
Macrophages / metabolism,  pathology
Macular Degeneration / complications*
Male
Middle Aged
Photochemotherapy*
Photosensitizing Agents / therapeutic use*
Porphyrins / therapeutic use*
Receptors, Cell Surface / metabolism
Retrospective Studies
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD34; 0/Antigens, Differentiation, Myelomonocytic; 0/Antigens, Thy-1; 0/CD68 antigen, human; 0/ENG protein, human; 0/Keratin-18; 0/Photosensitizing Agents; 0/Porphyrins; 0/Receptors, Cell Surface; 129497-78-5/verteporfin; EC 3.1.3.48/Antigens, CD45; EC 3.1.3.48/PTPRC protein, human

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