Document Detail


Influence of ventricular pressure drop on mitral annulus dynamics through the process of vortex ring formation.
MedLine Citation:
PMID:  17899379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several studies have suggested that the mitral annulus displacement and velocity in early diastole can be used as indicators of diastolic performance. The peak velocity of the mitral annulus away from the LV apex during early diastole, which indicates the rate of longitudinal expansion of the LV, is reduced in patients with impaired diastolic relaxation. With the intention of relating the trans-mitral flow to mitral annulus plane dynamics, we measured mitral annulus recoil force for different valve sizes, while applying an exponential pressure drop in a simplified model of the ventricle. The temporal changes in diameter of the valve during rapid filling phase were also considered. The process of ventricular vortex formation was studied together with the measurement of mitral annulus recoil force within different pressure drop conditions. Matching the vorticity contour plots with the recoil force measurements resulted in the fact that the magnitude of recoil is maximal once the vortex ring is about to pinch off, regardless of the valve size or the characteristics of ventricular pressure drop. This study showed that the mitral annulus recoil is maximal once occurs at the vortex formation time ranging from 3.5 to 4.5. It was also shown that the presence of leaflets would dissipate the annulus recoil force.
Authors:
Arash Kheradvar; Morteza Gharib
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Publication Detail:
Type:  Journal Article     Date:  2007-09-25
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  35     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-01-07     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2050-64     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, University of South Carolina, 300 Main Street, Columbia, SC 29208, USA. arashkh@engr.sc.edu
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MeSH Terms
Descriptor/Qualifier:
Atrial Function / physiology*
Blood Flow Velocity / physiology*
Blood Pressure / physiology*
Computer Simulation
Humans
Mitral Valve / physiology*
Models, Cardiovascular*
Nonlinear Dynamics
Ventricular Function*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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