Document Detail

Influence of venous congestion on blood-lymph transport of fluid and large molecules in the heat-injured dog's paw.
MedLine Citation:
PMID:  6116837     Owner:  NLM     Status:  MEDLINE    
Hind paws of anesthetized dogs were exposed to moderate continuous heat (45--52 degrees C). Lymph flow (L) was increased to 5.61 (SD 3.26) times control levels, lymph:plasma concentration ratios for total plasma protein (RT) were increased to 3.23 (SD 1.33), and for exogenous Dextran-110 (RD) to 8.41 (SD 4.00) times control levels. Selectivity of the blood-lymph barrier for individual plasma proteins was also decreased. Elevation of venous pressure during heating resulted in an increase of L in 5 out of 8 experiments, with no consistent change in RT or RD. Increased protein flux was thus closely coupled to increased volume flow. These observations are consistent with the presence and persistence of intercellular openings or gaps in the microvascular endothelium.
E M Renkin; C S Sloop; W L Joyner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lymphology     Volume:  14     ISSN:  0024-7766     ISO Abbreviation:  Lymphology     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1981-12-15     Completed Date:  1981-12-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0155112     Medline TA:  Lymphology     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
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MeSH Terms
Blood Proteins / analysis*
Foot Injuries*
Hot Temperature / adverse effects*
Hydrostatic Pressure
Lymph / analysis,  physiology*
Saphenous Vein / physiopathology
Veins / physiology*
Grant Support
Reg. No./Substance:
0/Blood Proteins

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